Results 221 to 230 of about 401,690 (283)

Diet–Microbiome–Immune Interactions at the Gut Mucosa in Food Allergy: Mechanisms, Gaps, and Therapeutic Implications

Allergy, EarlyView.
ABSTRACT Mucosal surfaces are sites of highly dynamic interactions among epithelial and immune cells, environmental exposures, particularly dietary inputs, and the diverse microbial communities and their metabolites. These elements continually influence each other to maintain homeostasis and ensure appropriate immune discrimination between pathogens ...
Clara Delaroque, Liam O'Mahony, Inge Kortekaas Krohn, Charlotte G. Mortz, Markus Ollert, Mahesh S. Desai   +5 more
wiley   +1 more source

Deficiency of Mitochondrial Fatty Acid Enzyme, CPT1A, Underlies Airway Epithelial Barrier Dysfunction in Severe Asthma

Allergy, EarlyView.
Mitochondrial fatty acid enzyme, CPT1A, is deficient in the airway epithelium of severe asthma patients. Restoration of CPT1A expression improved epithelial barrier integrity via increasing mitochondrial respiration and ATP production in airway epithelial cells. Restoration of deficient epithelial CPT1A may represent a new treatment approach for severe
Muyun Wang, Haiyang Hu, Kun Wang, Di Wu, Ximing Liao, Jing Gao, Tian Li, Wujian Xu, Shaoyong Gao, Qiang Li, Pankaj Kumar Bhavsar, Wei Gao, Kian Fan Chung   +12 more
wiley   +1 more source

Structural and cellular mechanisms of mucus plugging in the larger airways. [PDF]

Chin Med J Pulm Crit Care Med
Hu Z, Yang L, Ma Y, Chen J, Liu X.
europepmc   +1 more source

Cross-species systems analysis distinguishes inflammatory remodeling from primary mucus secretory failure in inflammatory bowel disease. [PDF]

Front Immunol
Xhumari J, Ojeda A, Akinsuyi OS, Roesch LFW.   +3 more
europepmc   +1 more source

Maintenance and disruption of mucous barrier homeostasis: the critical role of MUC5AC/MUC5B balance in airway diseases. [PDF]

Front Med (Lausanne)
Song Y, Wu X, Tian H, Liu Z.
europepmc   +1 more source

Airway Mucus Secretion

Physiology, 1990
Mucus secretion into the airways is mainly under vagal cholinergic control, and its volume and composition are modulated by sympathetic (adrenergic) and peptidergic mechanisms. Inflammatory mediators also change the secretion. The various compositions of mucus have been little explored, and the importance of its changes in disease is little understood.
JG Widdicombe, SE Webber
openaire   +2 more sources

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Airway goblet-cell mucus secretion

Trends in Pharmacological Sciences, 2001
A mucus hypersecretory phenotype is a dominant characteristic of chronic airways diseases such as chronic bronchitis and asthma. This phenotype develops following chronic exposure of the respiratory tract to particulate matter, allergens, irritants and/or pathogens.
exaly   +3 more sources