Results 221 to 230 of about 152,260 (296)
Integrative Zoology, EarlyView.We performed 16S rDNA sequencing and metabolite profiling for three sympatric lizard species—Teratoscincus roborowskii, Phrynocephalus axillaris, and Eremias roborowskii—and compared their goblet cell and enzyme activities in the digestive tract. Our study suggests that the dietary niche may promote divergence or convergence of microbiota across host ...
Yi Yang, Ziyi Wang, Ruichen Wu
wiley +1 more source
Integrative Zoology, EarlyView.Kaempferol modulates the tryptophan metabolism pathway by increasing the abundances of Christensenellaceae R7 group, Bacteroides, and Blautia and reducing that of Rikenellaceae RC9 gut group, thereby significantly increasing the levels of ILA and IAA. This process inhibits the activation of NF‐κB/NLRP3 signaling pathway, reduces pro‐inflammatory factor
Xiangyu Liu +3 more
wiley +1 more source
Allergic Sensitization to Inhalant Allergens in the Upper Respiratory Tract—the B Cell Side
Allergy, EarlyView.ABSTRACT Allergic diseases are on the rise worldwide, driven by respiratory epithelial barrier dysfunction that promotes sensitization to inhalant allergens such as pollen, dust mites, pet dander, and fungal spores. These antigens trigger IgE‐mediated immune responses that lead to diseases such as allergic rhinitis (AR) and asthma.
Ola Grimsholm +9 more
wiley +1 more source
Allergy, EarlyView.ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
F. Roth‐Walter +20 more
wiley +1 more source
Allergy, EarlyView.We exposed human nasal epithelial tissues to pollen from grasses grown under different climate treatments (temperature and CO2). Pollen weakened epithelial tight junctions and altered cytokine‐related gene expression, with similar protein‐level effects.
Tarleena Tossavainen +5 more
wiley +1 more source
Nasal Airway Transcriptome Reflects Selected Asthma‐Associated Gene Signatures in the Lower Airways
Allergy, EarlyView.Seven genes and two gene modules were consistently associated with asthma in both airway compartments in ARMS and were validated in ATLANTIS. The two modules reflected IL‐13 related inflammation and mast cell activity, respectively. Nasal gene signatures provide a non‐invasive proxy for selected bronchial asthma‐associated gene signatures. ARMS, Asthma
Hui Wen +22 more
wiley +1 more source
MAIT Cells Suppress IgE‐Mediated Asthma via IFNγ‐Dependent B Cell Regulation
Allergy, EarlyView.In this study, we demonstrate that MAIT cell antagonism during sensitization and challenge with HDM worsens the development of airway hyperreactivity without effects on type 2 or 17 associated cytokine production or lung inflammation. Rather, MAIT cells appear to regulate HDM‐induced asthma through direct inhibition of IgE production.
Angela M. Cannata +6 more
wiley +1 more source
Allergy, EarlyView.ABSTRACT Advances in asthma therapies have shown that clinical remission may be an achievable therapeutic goal for patients with asthma. This review discusses the current definitions of remission in asthma, the predictors of remission, airway inflammation/epithelial damage in asthma remission, airway remodeling, paradigms in defining remission and ...
Fatma Esra Gunaydin +4 more
wiley +1 more source
Tongue and Glottis Morphology of Cathartes aura and the Secret of Its Functional Adaptation
Acta Zoologica, EarlyView.ABSTRACT Cathartes aura, commonly known as the Turkey vulture, is a scavenger bird belonging to the family Cathartidae that is widely distributed throughout the Americas and classified as a New World vulture. Its diet primarily consists of small‐sized carcasses, predominantly of wild animals.
Jean Caio Figueiredo de Almeida +5 more
wiley +1 more source