Results 81 to 90 of about 851,832 (288)

Intrinsically Mitochondria‐Targeting Nanozyme via Coordination‐Assembly of Natural Quercetin for Cascade Antioxidant Therapy of Cerebral Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
This study uncovers that quercetin naturally targets mitochondria. By coordinating quercetin with Fe3+, we engineer an ultrasmall cascade nanozyme (MCN) with superoxide dismutase‐catalase activities. MCN crosses the damaged blood–brain barrier, scavenges mitochondrial ROS, prevents mitochondrial DNA leakage, and blocks the cGAS‐STING pathway, thereby ...
Wenxuan Zheng, Zhicheng Wang, Xin Zhou, Shuya Wang, Xiaojing Shi, Tingli Xiong, Ruishi Li, Yuting Lin, Zhen Chen, Jiawen Wei, Fei Li, Jinwen Ge, Kelong Ai, Chong Liu, Guiming Deng   +14 more
wiley   +1 more source

T2T Genome Assembly and Multi‐Omics Data Reveal Terrestrial Adaptation and Mucus Biosynthesis in Tropical Leatherleaf Slug (Laevicaulis alte)

Advanced Science, EarlyView.
A gap‐free genome assembly and multi‐omics comparison of the terrestrial slug Laevichaulis alte with an aquatic relative reveal that expansion of the VEGF family orchestrates mucus production, lipid metabolism, and immune defense—highlighting key molecular innovations for conquering life on land.
Gang Wang, Shaofang He, Zhongkai Wang, Aobo Pang, Xiaoli Sun, Rongchen Liu, Fang Wang, Sisi Chen, Zhijuan Bian, Dongcheng Wei, Liuhan Wu, Siyao Zhao, Qiuting Ji, Yiqi Sun, Niying Sun, Yushinta Fujaya, Boping Tang, Kianann Tan, Daizhen Zhang, Lianfu Chen   +19 more
wiley   +1 more source

Phytonutrient diet supplementation promotes beneficial Clostridia species and intestinal mucus secretion resulting in protection against enteric infection

Scientific Reports, 2015
Plant extracts, or phytonutrients, are used in traditional medicine practices as supplements to enhance the immune system and gain resistance to various infectious diseases and are used in animal production as health promoting feed additives.
M. Wlodarska, Benjamin P. Willing, David M. Bravo, B. Finlay   +3 more
semanticscholar   +1 more source

Some Characteristics of Para-Mucus Secretion.

Experimental Biology and Medicine, 1960
It has been reported from this laboratory that the topical application of iodoacetamide (IAA) or N-ethyl maleimide (NEM) solutions to the mucosa of canine gastric pouches will evoke a flow of mucinous secretion for many hours (1). This material had never been recognized before, and because its physiological significance is still unknown, it was ...
F, HOLLANDER, P, MAZURE, B J, RYBAK
openaire   +2 more sources

Nanomaterials for Allergy Diagnosis and Treatment: Advances, Opportunities and Translational Challenges

Advanced Science, EarlyView.
Nanomaterials offer dual applications in allergy management. For diagnosis, nanomaterials enhance analytical sensitivity and improve detection in specific IgE and functional assays such as the basophil activation test (BAT). For allergen‐specific immunotherapy, nanomaterials enable allergen masking and controlled release, and effectively modulate the ...
Madiha Habib, Shan Jiang, Joyce ZX Lee, CW Lim, HL Yeung, Nicki YH Leung, Patrick SC Leung, Ting F Leung, Christine YY Wai   +8 more
wiley   +1 more source

Neural control of airway mucus secretion

Biomedicine & Pharmacotherapy, 1990
Neural mechanisms contribute to the control of secretion of mucus in the airways of a number of animal species including humans. The nerves involved are adrenergic, cholinergic and non-adrenergic, non cholinergic (NANC) and contribute to greater or lesser degrees, depending upon the species, to secretion from submucosal glands and epithelial goblet ...
D F, Rogers, A, Dewar
openaire   +2 more sources

Nano‐Backpack Engineered Probiotics with Reactive Oxygen Species–Responsive Tungsten Release for Synergistic Therapy of Inflammatory Bowel Disease

Advanced Science, EarlyView.
An integrated probiotic system is engineered to execute a programmed therapeutic cascade against inflammatory bowel disease. Upon pathological signals, the system sequentially performs ROS scavenging, tungsten release, and selective pathogen suppression, thereby breaking the oxidative stress–dysbiosis cycle to remodel gut microbiota and reinforce ...
Yang Yang, Liucan Wang, Guoqing Chen, Yuanling Zhang, Jiarui Shi, Wenzhe Fan, Min Yu, Jixi Zhang, Hua Yang   +8 more
wiley   +1 more source

Inflammation promotes stomach epithelial defense by stimulating the secretion of antimicrobial peptides in the mucus

Gut Microbes
The mucus serves as a protective barrier in the gastrointestinal tract against microbial attacks. While its role extends beyond merely being a physical barrier, the extent of its active bactericidal properties remains unclear, and the mechanisms ...
Megi Vllahu, Antonia Voli, Valerio Licursi, Claudia Zagami, Antonella D’Amore, Jan Traulsen, Sara Woelffling, Monika Schmid, Robbie Crickley, Richard Lisle, Alexander Link, Alessandra Tosco, Thomas F. Meyer, Francesco Boccellato   +13 more
doaj   +1 more source

Mucoadhesive Peptide‐Catalase Self‐Assembled Nano‐Formulation for Effective Treatment of Mucosal Inflammatory Diseases

Advanced Science, EarlyView.
CR8L10 is self‐assembled with catalase (CAT) to form CR8L10@CAT nanocomplexes, which can anchor to mucosal surfaces via thiol‐disulfide exchange with mucin, thereby enhancing their mucosal retention. The efficient reactive oxygen species (ROS) scavenging at inflamed sites would then result in successful treatment in both the intravesical IC/BPS model ...
Xinzhu Li, Yuxuan Ma, Di He, Yingying Huang, Yutong Jiang, He Zhao, Shengjie Ge, Ruirui Zhao, Hejia Yuan, Wendi Jiang, Wenjun Zhu, Kai Liu, Han Zhang, Zhuang Liu   +13 more
wiley   +1 more source

Live imaging of airway epithelium reveals that mucociliary clearance modulates SARS-CoV-2 spread

Nature Communications
SARS-CoV-2 initiates infection in the conducting airways, where mucociliary clearance inhibits pathogen penetration. However, it is unclear how mucociliary clearance impacts SARS-CoV-2 spread after infection is established. To investigate viral spread at
Mark E. Becker, Laura Martin-Sancho, Lacy M. Simons, Michael D. McRaven, Sumit K. Chanda, Judd F. Hultquist, Thomas J. Hope   +6 more
doaj   +1 more source