Intestinal mucus components and secretion mechanisms: what we do and do not know
Experimental and Molecular Medicine, 2023 Damage to the colon mucus barrier, the first line of defense against microorganisms, is an important determinant of intestinal diseases such as inflammatory bowel disease and colorectal cancer, and disorder in extraintestinal organs.
Chunyan Song +5 more
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Disruption-induced mucus secretion: repair and protection. [PDF]
PLoS Biology, 2006 When a cell suffers a plasma membrane disruption, extracellular Ca(2+) rapidly diffuses into its cytosol, triggering there local homotypic and exocytotic membrane fusion events.
K Miyake, T Tanaka, P L McNeil
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Ductal Mucus Obstruction and Reduced Fluid Secretion Are Early Defects in Chronic Pancreatitis [PDF]
Frontiers in Physiology, 2018 Objective: Defective mucus production in the pancreas may be an important factor in the initiation and progression of chronic pancreatitis (CP), therefore we aimed to (i) investigate the qualitative and quantitative changes of mucus both in human CP and ...
Anita Balázs +20 more
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Dynamic changes in mucus thickness and ion secretion during Citrobacter rodentium infection and clearance. [PDF]
PLoS ONE, 2013 Citrobacter rodentium is an attaching and effacing pathogen used as a murine model for enteropathogenic Escherichia coli. The mucus layers are a complex matrix of molecules, and mucus swelling, hydration and permeability are affected by many factors ...
Jenny K Gustafsson +9 more
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Effects of Sodium Fluoride on Water and Acid Secretion, Soluble Mucus and Adherent Mucus of the Rat Stomach [PDF]
Canadian Journal of Gastroenterology, 2000 Chronic and acute ingestion of fluoride may lead to both structural and functional alterations of the gastric mucosa. The aim of this study was to investigate the effects of sodium fluoride on gastric secretion and mucosal barrier.
Kamel Gharzouli +3 more
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Xenopus: An alternative model system for identifying muco-active agents. [PDF]
PLoS ONE, 2018 The airway epithelium in human plays a central role as the first line of defense against environmental contaminants. Most respiratory diseases such as chronic obstructive pulmonary disease (COPD), asthma, and respiratory infections, disturb normal muco ...
Hyo Jung Sim +5 more
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Chronic Inflammation in Ulcerative Colitis Causes Long-Term Changes in Goblet Cell FunctionSummary
Cellular and Molecular Gastroenterology and Hepatology, 2022 Background & Aims: One of the features of ulcerative colitis (UC) is a defect in the protective mucus layer. This has been attributed to a reduced number of goblet cells (GCs).
Varsha Singh +10 more
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Mucus secretions in Cnidarian, an ecological, adaptive and evolutive tool
Advances in Oceanography and Limnology, 2022 Mucus secretion provides an interface with unique and multifunctional properties between the epithelial cells of many aquatic organisms and their surrounding environment.
Serena Savoca +4 more
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Effect of montelukast on platelet activating factor- and tachykinin induced mucus secretion in the rat [PDF]
, 2008 Background: Platelet activating factor and tachykinins (substance P, neurokinin A, neurokinin B) are important mediators contributing to increased airway secretion in the context of different types of respiratory diseases including acute and chronic ...
David A Groneberg +12 more
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Frontiers in Immunology, 2021 Mucus secretion is an important feature of asthma that highly correlates with morbidity. Current therapies, including administration of mucolytics and anti-inflammatory drugs, show limited effectiveness and durability, underscoring the need for novel ...
Hope Steele +5 more
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