Results 61 to 70 of about 760 (134)
, 2021 Abstract Structural Maintenance of Chromosomes (SMC) complexes contribute ubiquitously to chromosome organization-segregation. SMC proteins have a conserved architecture, with a dimerization hinge and an ATPase head domain separated by a long antiparallel intramolecular coiled-coil.
Josh Prince +7 more
openaire +1 more source
Mechanism of DNA entrapment by the MukBEF SMC complex and its inhibition by a viral DNA mimic
SummaryRing-like structural maintenance of chromosomes (SMC) complexes are crucial for genome organization and operate through mechanisms of DNA entrapment and loop extrusion. Here, we explore the DNA loading process of the bacterial SMC complex MukBEF. Using electron cryomicroscopy (cryo-EM), we demonstrate that ATP binding opens one of MukBEF’s three
Bürmann F +6 more
europepmc +2 more sources
Molecular Microbiology, Volume 122, Issue 1, Page 81-112, July 2024.In this review article, the diverse mechanisms by which bacterial chromatin proteins influence and are influenced by transcription and DNA supercoiling are discussed. Abstract DNA in bacterial chromosomes is organized into higher‐order structures by DNA‐binding proteins called nucleoid‐associated proteins (NAPs) or bacterial chromatin proteins (BCPs ...
Christine M. Hustmyer, Robert Landick
wiley +1 more source
Structural and biochemical studies of the S. cerevisiae condensin complex [PDF]
, 2020 The Structural Maintenance of Chromosomes (SMC) complex family forms an essential part of the genome’s organisational machinery in all domains of life. In eukaryotes condensin is one such complex that mediates the packaging of DNA for segregation during ...
Cawood, Christopher
core +1 more source
Archaea, Volume 2024, Issue 1, 2024.Archaeal species encode a diversity of chromatin proteins that play distinct roles in genome compaction. Although our understanding of the individual proteins has been growing, their contributions to higher‐order folding in the archaeal chromosome remain to be explored. In this study, we investigated the chromatin structure of Thermoplasma volcanium, a
Kirk Amerigo B. Aycardo +2 more
wiley +1 more source
Chromosome organization by a conserved condensin-ParB system in the actinobacterium Corynebacterium glutamicum [PDF]
, 2020 Higher-order chromosome folding and segregation are tightly regulated in all domains of life. In bacteria, details on nucleoid organization regulatory mechanisms and function remain poorly characterized, especially in non-model species.
Bramkamp, Marc +6 more
core +3 more sources
DNA packaging by molecular motors: from bacteriophage to human chromosomes [PDF]
Dense packaging of genomic DNA is crucial for organismal survival, as DNA length always far exceeds the dimensions of the cells that contain it. Organisms, therefore, use sophisticated machineries to package their genomes.
Earnshaw, William C., Prevo, Bram
core +2 more sources
Chromosome organization in bacteria: mechanistic insights into genome structure and function [PDF]
, 2019 Macromolecular ...
Dame, R.T. +2 more
core +2 more sources
A model for Escherichia coli chromosome packaging supports transcription factor-induced DNA domain formation [PDF]
, 2012 What physical mechanism leads to organization of a highly condensed and confined circular chromosome? Computational modeling shows that confinement-induced organization is able to overcome the chromosome's propensity to mix by the formation of ...
Babu +69 more
core +2 more sources
Physical models of bacterial chromosomes
, 2023 The interplay between bacterial chromosome organization and functions such as transcription and replication can be studied in increasing detail using novel experimental techniques.
Broedersz, Chase P., Harju, Janni
core