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Molecular Microbiology, Volume 122, Issue 1, Page 81-112, July 2024.In this review article, the diverse mechanisms by which bacterial chromatin proteins influence and are influenced by transcription and DNA supercoiling are discussed. Abstract DNA in bacterial chromosomes is organized into higher‐order structures by DNA‐binding proteins called nucleoid‐associated proteins (NAPs) or bacterial chromatin proteins (BCPs ...
Christine M. Hustmyer, Robert Landick
wiley +1 more source
Archaea, Volume 2024, Issue 1, 2024.Archaeal species encode a diversity of chromatin proteins that play distinct roles in genome compaction. Although our understanding of the individual proteins has been growing, their contributions to higher‐order folding in the archaeal chromosome remain to be explored. In this study, we investigated the chromatin structure of Thermoplasma volcanium, a
Kirk Amerigo B. Aycardo +2 more
wiley +1 more source
Mutational analysis of
Molecular Microbiology, 2012 SummaryBacterial condensin MukBEF is essential for global folding of the Escherichia coli chromosome. MukB, a SMC (structural maintenance of chromosome) protein, comprises the core of this complex and is responsible for its ATP‐modulated DNA binding and reshaping activities.
Weifeng, She +4 more
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Author response: MukB ATPases are regulated independently by the N- and C-terminal domains of MukF kleisin [PDF]
, 2018 The Escherichia coli SMC complex, MukBEF, acts in chromosome segregation. MukBEF shares the distinctive architecture of other SMC complexes, with one prominent difference; unlike other kleisins, MukF forms dimers through its N-terminal domain.
Baker, R +17 more
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Clamping of DNA shuts the condensin neck gate. [PDF]
, 2022 SignificanceDNA needs to be compacted to fit into nuclei and during cell division, when dense chromatids are formed for their mechanical segregation, a process that depends on the protein complex condensin. It forms and enlarges loops in DNA through loop
Rhodes, James +2 more
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Models for DNA organization by MatP and MukBEF.
, 2019 A. A matS-bridging model for DNA organization in the Ter macrodomain by MatP. MatP recognizes a 13-bp signature DNA sequence called matS that is present exclusively in the Ter macrodomain. There are 23 matS sites separated by one another by an average of
Zhong Qian (8119712) +2 more
core +1 more source
MukB colocalizes with the oriC region and is required for organization of the two Escherichia coli chromosome arms into separate cell halves. [PDF]
, 2007 The circular Escherichia coli chromosome is organized by bidirectional replication into two equal left and right arms (replichores). Each arm occupies a separate cell half, with the origin of replication (oriC) at mid-cell. E.
Pinskaya, M +14 more
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Overproduction of MukBEF and MukB induces transient growth arrest.
, 2013 Shown are the average growth curves (n between 2 and 8; SEM are shown when bigger than symbols) obtained after induction of MukB (pB), MukBEF (pBEF), MukEF (pEF) or SmtA (pSmtA). The cells harboring vector alone (pBAD) were used as a control.
Valentin V. Rybenkov (501513) +4 more
core +1 more source
Low-Copy-Number Plasmid Partitioning in Relation to E. coli Chromosomal Organization
, 2021 From complex multicellular organisms to the simplest of bacteria, all organisms must properly partition their DNA during cellular replication to ensure equal inheritance of genetic material. One protein key to the proper segregation of the E.
Wilkins, Brady
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Self-organised segregation of bacterial chromosomal origins
, 2018 In spite of much effort, many aspects of chromosome organisation and segregation in bacteria remain unclear. Even for Escherichia coli, the most widely studied bacterial model organism, we still do not know the underlying mechanisms.
Seán M. Murray +4 more
core +1 more source