Molecular basis for SMC rod formation and its dissolution upon DNA binding. [PDF]
, 2015 SMC condensin complexes are central modulators of chromosome superstructure in all branches of life. Their SMC subunits form a long intramolecular coiled coil, which connects a constitutive "hinge" dimerization domain with an ATP-regulated "head ...
Soh, Young-Min +69 more
core +1 more source
Asymmetric MukB ATPases are regulated independently by the N- and C-terminal domains of MukF kleisin
, 2017 The Escherichia coli SMC complex, MukBEF, acts in chromosome segregation. MukBEF shares the distinctive architecture of other SMC complexes, with one prominent difference; unlike other kleisins, MukF forms dimers through its N-terminal domain.
Lidia K. Arciszewska +5 more
core +1 more source
In vivo architecture and action of bacterial structural maintenance of chromosome proteins.
, 2012 SMC (structural maintenance of chromosome) proteins act ubiquitously in chromosome processing. In Escherichia coli, the SMC complex MukBEF plays roles in chromosome segregation and organization. We used single-molecule millisecond multicolor fluorescence
Leake, MC +5 more
core +1 more source
Structural Studies of a Bacterial Condensin Complex Reveal ATP-Dependent Disruption of Intersubunit Interactions [PDF]
, 2009 SummaryCondensins are key mediators of chromosome condensation across organisms. Like other condensins, the bacterial MukBEF condensin complex consists of an SMC family protein dimer containing two ATPase head domains, MukB, and two interacting subunits,
Joo, Keehyoung +11 more
core +1 more source
Mutational Analysis of Bacterial Condensins [PDF]
, 2011 Genetic information is carried on chromosomes in all organisms and chromosome is at the center of all life processes. The chromosome must be properly folded to fit into the cells.
She, Weifeng
core
Etude des mécanismes responsables de la cohésion des chromatides soeurs dans la bactérie
, 2022 During cell proliferation, the maintenance of genetic information is essential. In bacteria, replication and segregation are concomitant. Replication starts at the single, bidirectional origin of replication of bacterial chromosomes. Two replication arms
Challita, Jihane
core +1 more source
Multiscale Structuring of the E. coli Chromosome by Nucleoid-Associated and Condensin Proteins
, 2018 International audienceAs in eukaryotes, bacterial genomes are not randomly folded. Bacterial genetic information is generally carried on a circular chromosome with a single origin of replication from which two replication forks proceed bidirectionally ...
Mozziconacci, Julien +15 more
core +1 more source
Editorial: Chromosome architecture and DNA topology in prokaryotes. [PDF]
Front Microbiol, 2023 Basta T, Crozat E, Grainge I.
europepmc +1 more source
Small Molecule Condensin Inhibitors
, 2018 Condensins play a unique role in orchestrating the global folding of the chromosome, an essential cellular process, and contribute to human disease and bacterial pathogenicity.
Valentin V. Rybenkov (501513) +5 more
core +1 more source
Smc/ScpAB condensin 단백질의 구조적 연구
, 2013 학위논문(박사) - 한국과학기술원 : 생명과학과, 2013.2, [ v, 71 p. ]Chromosomes are condensed form in all living organisms. In prokaryotes, three groups of chromosome condensin complexes have been identified, Smc/ScpAB, MukBEF and a related MksBEF.
Shin, Ho-Chul, 신호철
core +1 more source