Results 41 to 50 of about 191,166 (218)

The Application of Ontologies in Multi-Agent Systems in the Energy Sector: A Scoping Review

Energies, 2019
Multi-agent systems are well-known for their expressiveness to explore interactions and knowledge representation in complex systems. Multi-agent systems have been applied in the energy domain since the 1990s.
Zheng Ma, Mette Jessen Schultz, Kristoffer Christensen, Magnus Værbak, Yves Demazeau, Bo Nørregaard Jørgensen   +5 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

An intelligent multi-layer, multi-agent MMG framework with amelioration of energy efficiency and future investment outlook, under the deregulated day-ahead and real-time market regime

Frontiers in Energy Research
This paper developed an intelligent multi-agent system (MAS) with a multi-layer framework for multi-microgrids (MMGs) using robust and modern communication patterns for deployed agents to achieve distributed tasks.
Kamran Mujahid, Abdullah Altamimi, Abdullah Altamimi, Syed Ali Abbas Kazmi, Zafar A. Khan, Zafar A. Khan, Bader Alharbi, Hamoud Alafnan, Halemah Alshehry, Aneeque A. Mir   +9 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Distributed adaptive iterative learning control for 2D multi agent systems

Electronics Letters
This letter addresses the output consensus problem for a class of two‐dimensional (2D) multi agent systems (MASs) described by Fornasini–Marchesini model.
Qingyuan Xu, Qingquan Mai, Boxian Wang, Kai Wan, Yunshan Wei   +4 more
doaj   +1 more source

Avoiding collaborative paradox in multi‐agent reinforcement learning

ETRI Journal, 2021
The collaboration productively interacting between multi‐agents has become an emerging issue in real‐world applications. In reinforcement learning, multi‐agent environments present challenges beyond tractable issues in single‐agent settings.
Hyunseok Kim, Seonghyun Kim, Donghun Lee, Ingook Jang   +3 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source