Results 81 to 90 of about 13,394,408 (251)

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers   +19 more
wiley   +1 more source

Electroencephalographic Normalization as a Biomarker of Clinical Recovery in Down Syndrome Regression Disorder

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Down syndrome regression disorder is a syndrome characterized by subacute loss of cognitive, behavioral, and functional abilities in individuals with Down syndrome. Electroencephalography abnormalities are frequently observed during evaluation, but it remains unclear whether these findings represent a dynamic marker of disease ...
Jonathan D. Santoro   +14 more
wiley   +1 more source

Long-Term Adaptivity in Distributed Intelligent Systems: Study of ViaBots in a Simulated Environment

open access: yesRobotics, 2019
This paper proposes a long-term adaptive distributed intelligent systems model which combines an organization theory and multi-agent paradigm—ViaBots.
Arturs Ardavs   +3 more
doaj   +1 more source

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian   +6 more
wiley   +1 more source

Agent-Based Participatory Simulations: Merging Multi-Agent Systems and Role-Playing Games [PDF]

open access: yes
In 2001, Olivier Barreteau proposed to jointly use multi-agent systems and role-playing games for purposes of research, training and negotiation support in the field of renewable resource management.
Shinichi Honiden, Paul Guyot
core  

Normative Multi-Agent Systems (Dagstuhl Seminar 12111)

open access: yes, 2012
This report documents the program and the outcomes of Dagstuhl Seminar 12111 ``Normative Multi-Agent Systems''. Normative systems are systems in the behavior of which norms play a role and which need normative concepts in order to be described or ...
Governatori, Guido   +6 more
core   +1 more source

Agent Environments for Multi-agent Systems – A Research Roadmap [PDF]

open access: yes, 2014
Ten years ago, researchers in multi-agent systems became more and more aware that agent systems consist of more than only agents. The series of workshops on Environments for Multi-Agent Systems (E4MAS 2004-2006) emerged from this awareness.
Weyns, Danny   +39 more
core   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem   +9 more
wiley   +1 more source

Neural Trust Model for Multi-agent Systems [PDF]

open access: yes
Introducing trust and reputation into multi-agent systems can significantly improve the quality and efficiency of the systems. The computational trust and reputation also creates an environment of survival of the fittest to help agents recognize and ...
Lu, Gehao
core   +1 more source

Eight challenges in modelling disease ecology in multi-host, multi-agent systems

open access: yesEpidemics, 2015
Many disease systems exhibit complexities not captured by current theoretical and empirical work. In particular, systems with multiple host species and multiple infectious agents (i.e., multi-host, multi-agent systems) require novel methods to extend the
Michael G. Buhnerkempe   +5 more
doaj   +1 more source

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