Results 81 to 90 of about 12,467,789 (199)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Formal Specification of Multi-Agent Systems

, 1995
In this paper the framework DESIRE, originally designed for formal specification of complex reasoning systems is used to specify a real-world multi-agent application on a conceptual level.
Keplicz, BD, Jennings, N. R., Brazier, FMT, Treur, J, Keplicz, B. D., Jennings, NR, Treur, J., Brazier, F. M. T.   +7 more
core  

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Developing Industrial Multi-Agent Systems (Invited Paper)

, 1995
The development and deployment of multi-agent systems in real world settings raises a number of important research issues and problems which must be overcome if Distributed AI (DAI) is to become a widespread solution technology.
Jennings, N. R., Corera, J., Corera, J, Jennings, NR, Laresgoiti, I, Laresgoiti, I.   +5 more
core  

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Contract Formation through Preemptive Normative Conflict Resolution [PDF]

, 2009
We explore a rule-based formalisation for contracts: the rules capture conditional norms, that is, they describe situations arising during the enactment of a multi-agent system, and norms that arise from these situations.
Norman, Timothy J., Vasconcelos, Wamberto, Norman, Timothy J   +2 more
core   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Multi-agent systems for power engineering applications - part 1 : Concepts, approaches and technical challenges [PDF]

, 2007
This is the first part of a 2-part paper that has arisen from the work of the IEEE Power Engineering Society's Multi-Agent Systems (MAS) Working Group. Part 1 of the paper examines the potential value of MAS technology to the power industry.
Funabashi, T, Funabashi, T., Hatziargyriou, ND, Catterson, V.M., Dimeas, A.L., Davidson, E.M., Davidson, EM, McArthur, S.D.J., McArthur Stephen, DJ, Ponci, F., Catterson, VM, Dimeas, AL, Hatziargyriou, N.D., Ponci, F   +13 more
core   +2 more sources

Multi-Agent Contextual Bandits for Multi-Objective Recommendation Systems [PDF]

ITM Web of Conferences
In this work, the use of multi-agent contextual bandits to optimize multi-objective recommendation systems in resource-constrained settings is examined.
Zhu Ziwen
doaj   +1 more source