Results 41 to 50 of about 776,504 (298)
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Multi objective elk herd optimization for efficient structural design
Scientific ReportsThis research presents an advancement of the Elk Herd Optimization targeting specific real-world multi-objective optimization problems, this algorithm is stated as the multi-objective Elk Herd Optimization (MOEHO).
Pinank Patel +7 more
doaj +1 more source
Multi-Objective Optimization Benchmarking Using DSCTool
Mathematics, 2020 By performing data analysis, statistical approaches are highly welcome to explore the data. Nowadays with the increases in computational power and the availability of big data in different domains, it is not enough to perform exploratory data analysis ...
Peter Korošec, Tome Eftimov
doaj +1 more source
Biomimetics, 2023 Satisfying various constraints and multiple objectives simultaneously is a significant challenge in solving constrained multi-objective optimization problems.
Yufei Yang, Changsheng Zhang
doaj +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Frontiers in Energy Research, 2022 In order to achieve good adaptability, medical bone implants for clinical applications need to have porous characteristics. From a biological and mechanical point of view, the design of porous structures requires both suitable porosities to facilitate ...
Rui Liu +3 more
doaj +1 more source
Multi-agent system for dynamic manufacturing system optimization [PDF]
, 2008 This paper deals with the application of multi-agent system concept for optimization of dynamic uncertain process. These problems are known to have a computationally demanding objective function, which could turn to be infeasible when large problems are ...
A.J. Gonzalez +6 more
core +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Pymoo: Multi-Objective Optimization in Python
IEEE Access, 2020 Python has become the programming language of choice for research and industry projects related to data science, machine learning, and deep learning. Since optimization is an inherent part of these research fields, more optimization related frameworks ...
Julian Blank, Kalyanmoy Deb
doaj +1 more source