Results 51 to 60 of about 334,534 (257)
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
, 2023 It is crucial to provide real-time performance in many applications, such as interactive and exploratory data analysis. In these settings, users often need to view subsets of query results quickly. It is challenging to deliver such results over large datasets for relational operators over multiple relations, such as join.
Ghadakchi, Vahid +6 more
openaire +2 more sources
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
IET Radar, Sonar & NavigationThe authors propose a multi‐agent, multi‐dimensional joint optimisation decision‐making strategy to tackle the challenges jammers encounter when interfering with multi‐functional radars, which possess advanced anti‐interference capabilities. The strategy
Minhong Sun, Shuai Yin, Deguo Zeng
doaj +1 more source
Consensus control of multi‐agent systems with switched linear dynamics
IET Control Theory & Applications, 2023 In this work, the consensus problem of multi‐agent systems is addressed whose agent dynamics are described by the switched linear system, and the interaction topology is a directed graph.
Yan Zhu
doaj +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Multi-agent RMax for Multi-Agent Multi-Armed Bandits
, 2022 In this paper, we provide PAC bounds for best-arm identification in multi-agent multi-armed bandits (MAMABs), via an algorithm we call multi-agent RMax (MARMax). In a MAMAB, the reward structure is expressed as a coordination graph, i.e., the total team reward is a sum over local reward functions that are conditioned on the actions of a subset of the ...
Bargiacchi, Eugenio +5 more
openaire +1 more source