An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Comparison of different Multiple-criteria decision analysis methods in the context of conceptual design: application to the development of a solar collector structure [PDF]
, 2014 At each stage of the product development process, the designers are facing an important task which consists of decision making. Two cases are observed: the problem of concept selection in conceptual design phases and, the problem of pre-dimensioning once
EL AMINE, Mehdi +2 more
core
An MAGDM Approach Combining Numerical Values with Uncertain Linguistic Information and Its Application in Evaluation of R&D Projects Xin-Bao Liu , Feng Pei , Jian-Bo Yang , Shan-Lin Yang [PDF]
International Journal of Computational Intelligence Systems, 2010 In multi-attribute group decision making (MAGDM) problems, decision attributes of alternatives are often considered as with quantitative and qualitative information.
Xin-Bao Liu +3 more
doaj +1 more source
Green Supplier Selection Based on Sequential Group Three-Way Decision Making
Mathematics, 2023 Environmental protection and sustainable development have become the consensus of all countries in the world. Enterprises must pay attention to the impact on the environment in their operations.
Jiekun Song, Xueli Leng, Zhicheng Liu
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Multi-attribute Group Decision Making Based on Granular Computing
工程科学与技术, 2013 :By simulating the process of human thinking,a solving method for multi-attribute group decision making problem based on granular computing was proposed. Firstly, mathematical description of granular computing structure model was discussed.
谭旭, 毛太田, 张少丁, 邹凯
doaj
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Entropy Method of Multi-Attribute Decision-Making Problems [PDF]
E3S Web of ConferencesFood choice aims to identify the solution totheexiguity of the food. It is possible to do this through diversification. Finding the best selection of food alternatives is the goal of food diversification..
Shanmugapriya P. +2 more
doaj +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Cybernetics and Information Technologies, 2015 In this paper we investigate the dynamic multi-attribute group decision making problems, in which all the attribute values are provided by multiple decision makers at different periods. In order to increase the level of overall satisfaction for the final
Lin Wei, Yan Guangle, Shi Yuwen
doaj +1 more source