Results 71 to 80 of about 16,897,989 (294)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

ON RANKING OF TRAPEZOIDAL INTUITIONISTIC FUZZY NUMBERS AND ITS APPLICATION TO MULTI ATTRIBUTE GROUP DECISION MAKING

Journal of New Theory, 2015
− This paper focuses on the study of two characteristics of trapezoidal intuitionistic fuzzynumber (TRIFN), viz., Value index and Ambiguity index. Based on these two indexes, we develop analgorithm for ranking of trapezoidal intuitionistic fuzzy number ...
Debaroti Das, Pijus Kanti De
doaj  

Preference Evaluation and Recommendation of Athletes for National Traditional Sports Training Using an Intelligent Method Based on Picture Fuzzy Knowledge

IEEE Access
In sports, athletes’ initial training is crucial for their whole career. Initial training at the relevant board athletes are professionally trained for national and international competitions.
Xiaoyu Cao, Han Liu
doaj   +1 more source

MULTIMOORA strategy for solving multi-attribute group decision making (MAGDM) in trapezoidal neutrosophic number environment

CAAI Transactions on Intelligence Technology, 2020
The main purpose of this study is to bring in a new extension of multi-objective optimisation on the basis of ratio analysis plus full multiplicative form (MULTIMOORA) in trapezoidal neutrosophic number (TrNN) environment.
Surapati Pramanik, Rama Mallick, Rama Mallick   +2 more
doaj   +1 more source

Modelling and optimizing multiple attribute decisions by using fuzzy sets [PDF]

The purpose of this paper is to present a coherent perspective of modeling and optimizing multiple attribute decisions by using fuzzy sets. In management practice we face most of the time the situation in which a problem have several possible solutions ...
Adina NEGRUSA, Gh. Gh. IONESCU
core  

Cubic q-Rung Orthopair Fuzzy Heronian Mean Operators and Their Applications to Multi-Attribute Group Decision Making

, 2020
The cubic q-rung orthopair fuzzy set (Cq-ROFS) contains much more information to determine the interval valued q-rung orthopair fuzzy sets (IVq-ROFSs) and q-rung orthopair fuzzy sets (q-ROFSs) simultaneously for coping with the vagueness in information ...
Tahir Mahmood, Zeeshan Ali, Baosheng Zhang, Qaisar Khan, Shouzhen Zeng, Jabbar Ahmmad   +5 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Pythagorean Fuzzy Interaction Muirhead Means with Their Application to Multi-Attribute Group Decision-Making

Information, 2018
Due to the increased complexity of real decision-making problems, representing attribute values correctly and appropriately is always a challenge. The recently proposed Pythagorean fuzzy set (PFS) is a powerful and useful tool for handling fuzziness and ...
Yuan Xu, Xiaopu Shang, Jun Wang
doaj   +1 more source