Results 31 to 40 of about 7,434 (257)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Digital Twin-Enabled Decision Support in Mission Engineering and Route Planning

Systems, 2021
This article presents a Model-Based Systems Engineering (MBSE) methodology for the development of a Digital Twin (DT) for an Unmanned Aerial System (UAS) with the ability to demonstrate route selection capability with a Mission Engineering (ME) focus. It
Eugene Boon Kien Lee, Douglas L. Van Bossuyt, Jason F. Bickford   +2 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Decision Support System for Porang Land Selection based on Multi Attribute Utility Theory (MAUT)

Sistemasi: Jurnal Sistem Informasi
This study aims to develop a web-based decision support system using the Multi-Attribute Utility Theory (MAUT) algorithm to assess land suitability for porang cultivation.
Najirah Umar, Muhammad Idris, Agus Rahmat   +2 more
doaj   +1 more source

Multi-Attribute Utility Theory: A Psychological Perspective

Psychologica Belgica, 1982
Multi-attribute utility theory is discussed from a psychological point of view. The various independence assumptions underlying the riskless additive utility model, the additive expected utility model, the multiplicative expected utility model, and the quasi-additive expected utility model are formulated and illustrated.
openaire   +3 more sources

Implementation of Multi-Attribute Utility Theory (MAUT) method for selecting diplomats

IOP Conference Series: Materials Science and Engineering, 2021
Abstract Diplomatic relations between countries increasingly show how important the meaning of relations between these countries. Representatives are needed in order to establish cooperative relationships in several fields such as culture, politics, and education.
I Taufik, C N Alam, Z Mustofa, A Rusdiana, W Uriawan   +4 more
openaire   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Implementasi Metode Multi Attribute Utility Theory pada Sistem Pendukung Keputusan dalam Pemilihan Siswa Unggulan

Edumatic
Vocational School of Al Furqon is a private school that annually holds an election of excellent students. Vocational school Al Furqon selects excellent students manually so that the results of the assessment of superior students are less effective.
Rizky Nurhaliza, Nurwati Nurwati, Santoso Santoso   +2 more
doaj   +1 more source