Results 41 to 50 of about 7,420 (258)
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Developing Stochastic Additive Utility Method (UTA) Considering the Possible Dependency among Criteria [PDF]
مدیریت صنعتی, 2019 Objective: One of the well-known methods as to Multi Attribute Utility Theory (MAUT) in the field of decision making is Utility Additive Method (UTA), which has been developed over time.
Mahnaz Hosseinzadeh +3 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Journal of Asian Architecture and Building Engineering, 2018 As an alternative method for architectural regeneration, remodeling is drawing keen attention. However, it has turned out that post-occupancy satisfaction is quite low.
Eunhwa Hong, Jaeho Cho, Jaeyoul Chun
doaj +1 more source
Patria Artha Technological Journal, 2019 Pemilihan tenaga kesehatan teladan merupakan kegiatan rutin setiap tahun oleh Dinas Kesehatan Kota Ternate yang bertujuan untuk memberi penghargaan kepada mereka yang sudah mengabdikan diri di PUSKESMAS.
Sitti Ningsih +2 more
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Sistemasi: Jurnal Sistem InformasiCurrently developing information technology can be used by village governments in order to increase the public reach of village governments for the community by providing easy access to information as well as developing better, transparent, effective and
Diana Asmarani Siregar +1 more
doaj +1 more source
A new hybrid decision support tool for evaluating the sustainability of mining projects
International Journal of Mining Science and Technology, 2018 The integration of sustainable development challenges and opportunities into the decision making process during the design and/or implementation of multi-disciplinary mining projects is generally not supported by decision support systems (DSS).
S. Kamenopoulos +2 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Selecting essential information for biosurveillance--a multi-criteria decision analysis.
PLoS ONE, 2014 The National Strategy for Biosurveillance defines biosurveillance as "the process of gathering, integrating, interpreting, and communicating essential information related to all-hazards threats or disease activity affecting human, animal, or plant health
Nicholas Generous +7 more
doaj +1 more source