Results 41 to 50 of about 203,085 (305)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Penerapan Metode Multi-Attribute Utility Theory (MAUT) pada Pemilihan Broadcasting Terbaik

JURNAL MEDIA INFORMATIKA BUDIDARMA, 2023
In an increasingly sophisticated era and increasingly modern life, entertaining content makes Broadcasting a promising job field. This resulted in many people being interested in broadcasting. Broadcasting is a job related to broadcasting. All parties who participate in broadcasting, both cameramen, presenters, content creators, writer creators and so ...
Karya Suhada, Saludin Saludin, Abdurrahman Sadikin, Indah Kusuma Dewi, Fifto Nugroho   +4 more
openaire   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A view from the Bridge: agreement between the SF-6D utility algorithm and the Health utilities Index [PDF]

, 2003
BACKGROUND: The SF-6D is a new health state classification and utility scoring system based on 6 dimensions (‘6D’) of the Short Form 36, and permits a ‘‘bridging’’ transformation between SF-36 responses and utilities. The Health Utilities Index, mark 3
Brazier, Brazier, Drummond, Drummond, Feeny, Feeny, Fryback, Hohnloser, Keeney, Kind, Nichol, Samsa, Torrance, Ware, Ware   +14 more
core   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Multi-Criteria Analysis of Factors Use Level: The Case of Water for Irrigation [PDF]

In this paper we present a methodology to analyse input use in the agricultural sector. The novelty of the theoretical model explained is that it has been developed considering a multi-criteria environment.
José A. Gómez-Limón, Laura Riesgo, Manuel Arriaza   +2 more
core   +3 more sources

Decision Support System for Porang Land Selection based on Multi Attribute Utility Theory (MAUT)

Sistemasi: Jurnal Sistem Informasi
This study aims to develop a web-based decision support system using the Multi-Attribute Utility Theory (MAUT) algorithm to assess land suitability for porang cultivation.
Najirah Umar, Muhammad Idris, Agus Rahmat   +2 more
doaj   +1 more source

Multi-Attribute Utility Theory: A Psychological Perspective

Psychologica Belgica, 1982
Multi-attribute utility theory is discussed from a psychological point of view. The various independence assumptions underlying the riskless additive utility model, the additive expected utility model, the multiplicative expected utility model, and the quasi-additive expected utility model are formulated and illustrated.
openaire   +3 more sources

A heuristic approach for the allocation of resources in large-scale computing infrastructures [PDF]

, 2015
An increasing number of enterprise applications are intensive in their consumption of IT, but are infrequently used. Consequently, organizations either host an oversized IT infrastructure or they are incapable of realizing the benefits of new ...
Alrawahi, Amazon, Armbrust, Backhaus, Bapna, Brynjolfsson, Carr, Cripps, Dash, Davenport, Foster, Garey, Garg, Hey, Hooker, Lai, Lehmann, Lewis, Leyton-Brown, Leyton-Brown, M. Vaquero, Marshall, Milojičić, Mossmann, Neumann, Nissan, Nurmi, Pekeĉ, Pepple, Rardin, Reiss, Roberts, Schnizler, Shneidman, Siegle, Smidt, Sotomayor, Stösser, Stösser, Vries   +39 more
core   +2 more sources