Results 41 to 50 of about 593,318 (265)
IEEE AccessEfficient task scheduling is fundamental to real-time systems, where minimizing deadline misses and improving stability and determinism are the main goals.
Mahdi Seyfipoor +2 more
doaj +1 more source
Mapping the evolution of mitochondrial complex I through structural variation
FEBS Letters, EarlyView.Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin +2 more
wiley +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
An Efficient Racetrack Cache Architecture for Performance-Area-Energy Co-Optimization
IEEE AccessPrior RTM cache architectures, originally designed for smaller caches, become suboptimal when scaled to larger RTM Last-Level caches (LLCs), because they prioritize performance over energy and area efficiency.
Fazal Hameed
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Multi-core Decision Diagrams [PDF]
, 2018 Decision diagrams are fundamental data structures that revolutionized fields such as model checking, automated reasoning and decision processes. As performance gains in the current era mostly come from parallel processing, an ongoing challenge is to develop data structures and algorithms for modern multicore architectures.
van Dijk, Tom, van de Pol, Jaco
openaire +2 more sources
GDNF‐RET signaling drives pulmonary neuroendocrine cell hyperplasia and allergic airway inflammation
FEBS Letters, EarlyView.A neuroimmune interaction centered on the PNEC‐ILC2 axis in an asthma model. PNEC‐derived CGRP activates nearby ILC2s, which then release cytokines, including IL‐5 and IL‐13. These cytokines promote eosinophil and macrophage infiltration. Subsequently, GDNF produced by these cells induces PNEC hyperplasia via the GDNF receptors, RET and GFRα1 ...
Tasuku Kawano +3 more
wiley +1 more source
Early-Stage Planning of Switched-Capacitor Converters in a Heterogeneous Chip
IEEE Access, 2020 The switched-capacitor converter (SCC) has been widely used for voltage regulation in multicore chips, where energy efficiency is the major concern. However as the overhead to integrate SCCs in a chip is non-negligible, the SCCs could not be overused ...
Leilei Wang +3 more
doaj +1 more source