Results 41 to 50 of about 1,347,779 (299)

Design and implementation of a dynamic deployment based on heterogeneous processor

Dianzi Jishu Yingyong
Aiming at the real-time switching and flexible intelligent invocation requirements of various life services supported by satellites, a scheme for real-time, efficient and dynamic switching and deployment of processor functions is designed based on the ...
Qian Hongwen, Chen Guangwei
doaj   +1 more source

Microfluidic System Protocols for Integrated On-Chip Communications and Cooling

IEEE Access, 2017
The advancements in multi-core central processing units have attracted new designs ranging from mechanisms of packing higher number of transistors into the small space, new techniques for communications (e.g., wireless network on chips), or new ...
Stefanus A. Wirdatmadja, Dmitri Moltchanov, Sasitharan Balasubramaniam, Yevgeni Koucheryavy   +3 more
doaj   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Enhancing Solar Convection Analysis With Multi‐Core Processors and GPUs

Engineering Reports
In the realm of astrophysical numerical calculations, the demand for enhanced computing power is imperative. The time‐consuming nature of calculations, particularly in the domain of solar convection, poses a significant challenge for Astrophysicists ...
Arash Heidari, Zahra Amiri, Mohammad Ali Jabraeil Jamali, Nima Jafari Navimipour   +3 more
doaj   +1 more source

Architectural-Space Exploration of Heterogeneous Reliability and Checkpointing Modes for Out-of-Order Superscalar Processors

IEEE Access, 2019
State-of-the-art reliability techniques and mechanisms deploy full-scale redundancy, like double or triple modular redundancy (DMR, TMR), on different layers of the computing stack to detect and/or correct such transient faults.
Bharath Srinivas Prabakaran, Mihika Dave, Florian Kriebel, Semeen Rehman, Muhammad Shafique   +4 more
doaj   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Optimizing Large Language Models on Multi-Core CPUs: A Case Study of the BERT Model

Applied Sciences
The BERT model is regarded as the cornerstone of various pre-trained large language models that have achieved promising results in recent years. This article investigates how to optimize the BERT model in terms of fine-tuning speed and prediction ...
Lanxin Zhao, Wanrong Gao, Jianbin Fang
doaj   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

NeuroFlow: A General Purpose Spiking Neural Network Simulation Platform using Customizable Processors

Frontiers in Neuroscience, 2016
NeuroFlow is a scalable spiking neural network simulation platform for off-the-shelf high performance computing systems using customizable hardware processors such as Field-Programmable Gate Arrays (FPGAs).
Kit eCheung, Kit eCheung, Simon R Schultz, Wayne eLuk   +3 more
doaj   +1 more source