Results 151 to 160 of about 79,223 (384)

Immunoinformatics design and synthesis of a multi-epitope vaccine against Helicobacter pylori based on lipid nanoparticles

Scientific Reports
Helicobacter pylori (H. pylori) is responsible for various chronic or acute diseases, such as stomach ulcers, dyspepsia, peptic ulcers, gastroesophageal reflux, gastritis, lymphoma, and stomach cancers.
A. Jebali, Azam Esmaeilzadeh, M. K. Esmaeilzadeh, Sadeq Shabani   +3 more
semanticscholar   +1 more source

A Unique Chimeric RNA: ERCC1‐iASPP Drives Benzo[a]pyrene‐Induced Lung Carcinogenesis via Dual Coding and Non‐Coding Mechanisms

Advanced Science, EarlyView.
The chimeric RNA ERCC1‐iASPP possesses dual coding and non‐coding functions, synergistically accelerating the process of cellular malignant transformation. Abstract Genetic variation at 19q13.3 critically modulates chemical carcinogen‐induced lung carcinogenesis, particularly in mediating the activity of benzo[a]pyrene (B[a]P), a major polycyclic ...
Mingming Shan, Mingyang Xiao, Liang Zhang, Shen Wang, Jiahang Wu, Kang Cao, Yujin Li, Guopei Zhang, Junwei Xie, Xiaobo Lu   +9 more
wiley   +1 more source

Identification and prioritisation of potential vaccine candidates using subtractive proteomics and designing of a multi-epitope vaccine against Wuchereria bancrofti

Scientific Reports
This study employed subtractive proteomics and immunoinformatics to analyze the Wuchereria bancrofti proteome and identify potential therapeutic targets, with a focus on designing a vaccine against the parasite species.
Murali Aarthy, G. N. Pandiyan, R. Paramasivan, Ashwani Kumar, Bhavna Gupta   +4 more
semanticscholar   +1 more source

Safety and Efficacy of Adoptive Transfer of Stem Cell Memory Enriched Virus Specific T Cells against CMV and EBV

Advanced Science, EarlyView.
This study finds that CD8⁺ TSCM cells exhibit superior self‐renewal, differentiation, and antiviral activity. Transcriptome and epigenome analyses highlight MAPK cascade regulation in TSCM cells. In vivo, virus‐specific TSCM cells show enhanced persistence and tumor protection.
Xun‐Hong Cao, Xu‐Ying Pei, Yuan‐Yuan Zhang, Juan Xie, Jing‐Wei Tu, Zhuo‐Jun Liu, Yi‐Yang Ding, Chen‐Hua Yan, Yu‐Hong Chen, Yu Wang, Lan‐Ping Xu, Xiao‐Hui Zhang, Xiao‐Jun Huang, Xiang‐Yu Zhao   +13 more
wiley   +1 more source

Size‐Dependent Ultrasound Activation of Thrombin Catalytic Activity by Mechano‐Nanoswitches

Advanced Science, EarlyView.
The fundamental principles linking nanoparticle (NP) physicochemical properties to their interactions with sonomechanical forces are not well‐defined. This work systematically investigates the size‐dependent ultrasound activation of thrombin using different‐sized mechano‐nanoswitches, which provides critical insights into the role of NP size in nano ...
Menghan Xiao, Zhihuan Liao, Junliang Chen, Xiong Zuo, Jiangting Zeng, Xiangfu Du, Zihao Teng, Johannes Hahmann, Andreas Herrmann, Shuaidong Huo   +9 more
wiley   +1 more source

Immunization expands B cells specific to HIV-1 V3 glycan in mice and macaques. [PDF]

, 2019
Broadly neutralizing monoclonal antibodies protect against infection with HIV-1 in animal models, suggesting that a vaccine that elicits these antibodies would be protective in humans.
Abernathy, Morgan E, Barnes, Christopher O, Bauer, Jens, Bjorkman, Pamela J, Cohen, Alexander A, Escolano, Amelia, Gao, Han, Gautam, Rajeev, Gazumyan, Anna, Golijanin, Jovana, Gristick, Harry B, Irvine, Darrell J, Keeffe, Jennifer R, Martin, Malcolm A, McGuire, Andrew T, Merkenschlager, Julia, Montefiori, David C, Nogueira, Lilian, Nussenzweig, Michel C, Oliveira, Thiago Y, Pai, Joy, Seaman, Michael S, Silva, Murillo, Stamatatos, Leonidas, Voll, Alisa V, Wang, Haoqing, Wang, Zijun, Wells, Lance, West, Anthony P, Yao, Kai-Hui, Yost, Daniel, Zhao, Peng   +31 more
core  

Unique Aerofoil‐Structured Microfluidics for High Throughput Lipid Nanoparticle Formulation Screening and Scale‐up

Advanced Science, EarlyView.
This study presents aerofoiled microfluidic structures optimized for efficient mixing and lipid nanoparticle (LNP) formation across broad flow rates. Based on this design, two dedicated systems are introduced: MiNANO‐form for high‐throughput formulation screening and MiNANO‐scale for continuous large‐scale production, enabling reproducible, high ...
Dongsheng Liu, Mingzhi Yu, Yuguo Zhang, Allen Mathew, Tianyu Guan, Liang Yao, Xianqing Wang, Wenxin Wang, Nan Zhang   +8 more
wiley   +1 more source

Design of a multi-epitope protein vaccine against herpes simplex virus, human papillomavirus and Chlamydia trachomatis as the main causes of sexually transmitted diseases

, 2021
Hesam Dorosti, Sedigheh Eskandari, Mahboubeh Zarei, Navid Nezafat, Younes Ghasemi   +4 more
openalex   +1 more source

The Prefusogenic Intermediate of HIV-1 gp41 Contains Exposed C-peptide Regions [PDF]

, 2003
The human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein is composed of a complex between the surface subunit gp120, which binds to cellular receptors, and the transmembrane subunit gp41.
Chan, David C., Koshiba, Takumi
core  

Designing a Candidate Multi-Epitope Vaccine against Transmissible Gastroenteritis Virus Based on Immunoinformatic and Molecular Dynamics

International Journal of Molecular Sciences
Transmissible gastroenteritis virus (TGEV) is an etiological agent of enteric disease that results in high mortality rates in piglets. The economic impact of the virus is considerable, causing significant losses to the pig industry. The development of an
Yihan Bai, Mingxia Zhou, Naidong Wang, Yi Yang, Dongliang Wang   +4 more
semanticscholar   +1 more source