Results 251 to 260 of about 36,032 (319)

Advancing dengue vaccine development: Challenges, innovations, and the path toward global protection

Pediatric Investigation, EarlyView.
Dengue vaccine development faces challenges, including antibody‐dependent enhancement and serotype‐specific immunity. This review highlights licensed vaccines, CYD‐TDV, TAK‐003, and Butantan‐DV, and explores strategies for achieving effective multivalent protection.
Ran Wang, Bridget Kim, Hridesh Mishra, Kevin C. Kain   +3 more
wiley   +1 more source

Key Regulators of Parasite Biology Viewed Through a Post‐Translational Modification Repertoire

PROTEOMICS, EarlyView.
ABSTRACT Parasites are the leading causes of morbidity and mortality in both humans and animals, imposing substantial socioeconomic burdens worldwide. Controlling parasitic diseases has become one of the key issues in achieving “One Health”. Most parasites have sophisticated life cycles exhibiting progressive developmental stages, morphologies, and ...
Naiwen Zhang, Ning Jiang, Qijun Chen
wiley   +1 more source

Design of a Multi-Epitope Vaccine against the Glycoproteins of Newcastle Disease Virus by Using an Immunoinformatics Approach. [PDF]

ACS Omega
Randriamamisolonirina NT, Razafindrafara MS, Maminiaina OF.   +2 more
europepmc   +1 more source

Computational design of multi-epitope vaccine against Hepatitis C Virus infection using immunoinformatics techniques. [PDF]

PLoS One
Zubair S, Parvaiz F, Abualait T, Al-Regaiey K, Anwar T, Zafar M, Kaleem I, Bashir S.   +7 more
europepmc   +1 more source

A Multiscale Quantitative Systems Pharmacology Model for the Development and Optimization of mRNA Vaccines

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT The unprecedented effort to cope with the COVID‐19 pandemic has unlocked the potential of mRNA vaccines as a powerful technology, set to become increasingly pervasive in the years to come. As in other areas of drug development, mathematical modeling is a pivotal tool to support and expedite the mRNA vaccine development process.
Lorenzo Dasti, Stefano Giampiccolo, Elisa Pettinà, Giada Fiandaca, Natascia Zangani, Lorena Leonardelli, Fabio De Lima Hedayioglu, Elio Campanile, Luca Marchetti   +8 more
wiley   +1 more source

Designing a multi-epitope vaccine candidate against human rhinovirus C utilizing immunoinformatics approach. [PDF]

Front Immunol
Mamun TI, Ali MA, Hosen MN, Rahman J, Islam MA, Akib MG, Zaman K, Rahman MM, Hossain FMA, Ibenmoussa S, Bourhia M, Dawoud TM.   +11 more
europepmc   +1 more source

Viral Dynamic Models During COVID‐19: Are We Ready for the Next Pandemic?

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Mathematical models have been used for about 30 years to improve our understanding of virus‐host interaction, in particular during chronic infections. During the COVID‐19 pandemic, these models have been used to provide insights into the natural history of acute SARS‐CoV‐2 infection, optimize antiviral treatment strategies, understand factors ...
Aurelien Marc, Joshua T. Schiffer, France Mentré, Alan S. Perelson, Jérémie Guedj   +4 more
wiley   +1 more source

‘Attitude Problems’: Racializing Hierarchies of Affect in Post‐Brown U.S. Science Education

Science Education, EarlyView.
ABSTRACT Attending to the affect of minoritized students now appears crucial to promoting just and dignity‐affirming science education. Yet, elevating affect as an objective of science learning has a history that predates equity reforms. This study explores the politics of scientific uptakes of affect that have long served to mark hierarchical ...
Kathryn L. Kirchgasler
wiley   +1 more source

Balancing allocative and dynamic efficiency with redundant R&D allocation: The role of organizational proximity and centralization

Strategic Management Journal, EarlyView.
Abstract Research Summary Resource‐based‐view scholars have mainly examined two resource allocation approaches for competitive advantage in multiunit firms: resource sharing and resource redeployment. These approaches emphasize allocative efficiency—the optimal allocation of resources to maximize their current value. In technology‐intensive industries,
Vivek Tandon, Anand Nandkumar, Ronak Mogra, Kannan Srikanth   +3 more
wiley   +1 more source

One Health Approach to the Computational Design of a Lipoprotein-Based Multi-Epitope Vaccine Against Human and Livestock Tuberculosis. [PDF]

Int J Mol Sci
Shey RA, Nchanji GT, Stong TYA, Yaah NE, Shintouo CM, Yengo BN, Nebangwa DN, Efeti MT, Chick JA, Ayuk AB, Gwei KY, Lemoge AA, Vanhamme L, Ghogomu SM, Souopgui J.   +14 more
europepmc   +1 more source