A conserved capsid-based multi-epitope vaccine targeting dengue virus serotypes (DENV1-4): an integrated computational and in vivo study. [PDF]
Khatrawi EM +4 more
europepmc +1 more source
ABSTRACT Sub‐Saharan Africa (SSA) faces a unique cancer burden, characterized by a disproportionately high mortality‐to‐incidence ratio, a large share of infection‐related cancers, and distinct environmental exposures. Implementation of national policies on primary prevention is limited, and public literacy regarding cancer risk and curability remains ...
Anthony Kityo +14 more
wiley +1 more source
Computational design and immunoinformatics validation of a T cell multi-epitope vaccine targeting glioblastoma stem cells. [PDF]
Salahlou R +4 more
europepmc +1 more source
Abstract Objective This study aims to evaluate the longitudinal clearance rates of high‐risk human papillomavirus (hr‐HPV) and the incidence of clinical recurrence (defined by abnormal cytology or histologically confirmed cervical intraepithelial neoplasia; CIN) at 6 and 18 months post‐loop electrosurgical excision procedure (LEEP), characterizing the ...
Praew Sittichivapak, Pattama Chaopotong
wiley +1 more source
Immuno-Informatics Design of Multi-Epitope Vaccine Candidate Against <i>Anaplasma phagocytophilum</i> Using Major Surface Protein 4 (MSP-4) Antigen. [PDF]
Malgwi SA +5 more
europepmc +1 more source
Engineering Bacteria for Medicine: Delivery, Diagnosis, and Therapy
ABSTRACT With rapid advances in synthetic biology and genetic engineering, genetically engineered bacteria (GEB) have emerged as a promising platform for biological therapy, addressing key limitations of conventional drug delivery systems and demonstrating significant clinical potential.
Shiyu Xia +11 more
wiley +1 more source
Correction: Immunoinformatics-driven multi-epitope vaccine design targeting PSMA, STEAP1, and B7H3 for prostate cancer. [PDF]
Runtunuwu SVBE +12 more
europepmc +1 more source
This review systematically summarizes the central role of cysteine peptidases in modulating antigen‐presenting cell (APC) function and antitumor immune responses, highlighting their critical significance in overcoming tumor immune evasion. Current research has established that cysteine peptidase subtypes, including cathepsins B, S, L, and X, exert ...
Yimao Wu +7 more
wiley +1 more source
Computational design of a novel multi-epitope vaccine candidate against group A rotavirus. [PDF]
Pajand O +5 more
europepmc +1 more source
Advances in Immunological Combination Therapy for Colorectal Cancer
Review the progress of combined immunotherapy for colorectal cancer. ABSTRACT Immune checkpoint inhibitors (ICIs) have been utilized extensively and shown to be therapeutically beneficial in the treatment of solid tumors in recent years. Nonetheless, considerable heterogeneity in Colorectal cancer (CRC) requires careful consideration.
Jiayue Wu +7 more
wiley +1 more source

