Results 71 to 80 of about 36,032 (319)

HBsAg-vectored DNA vaccines elicit concomitant protective responses to multiple CTL epitopes relevant in human disease. [PDF]

, 2008
Vaccines capable of controlling neoplastic and infectious diseases which depend on the cellular immune response for their resolution, have proven difficult to develop.
Allan Gould, Dekun Chen, Jacqueline Kattenbelt, Melanie Barnes, Michael Mather, Oscar Haigh, Robert R. Tindle, Scott Thomson   +7 more
core   +1 more source

Improved induction of anti-melanoma T cells by adenovirus-5/3 fiber modification to target human DCs [PDF]

, 2018
To mount a strong anti-tumor immune response, non T cell inflamed (cold) tumors may require combination treatment encompassing vaccine strategies preceding checkpoint inhibition.
Chondronasiou, Dafni, Curiel, David T, de Gruijl, Tanja D, Dmitriev, Igor, Eisden, Tracy-Jane T. H. D, Hooijberg, Erik, Icyuz, Mert, Matthews, Qiana L, Stam, Anita G.M, van de Ven, Rieneke   +9 more
core   +3 more sources

Immunoinformatics Approach to Design a Multi-Epitope Vaccine against Cutaneous Leishmaniasis

Vaccines, 2023
Cutaneous Leishmaniasis (CL), a neglected vector-borne disease caused by protozoan parasite Leishmania major (L. major), is a major public health concern, and the development of new strategies to reduce the disease incidence has become a top priority.
Shumaila Naz, Aiman Aroosh, Ayse Caner, Esra Atalay Şahar, Seray Toz, Yusuf Ozbel, Sumra Wajid Abbasi   +6 more
openaire   +4 more sources

Co‐expression of HSV‐1 ICP34.5 enhances the expression of gene delivered by self‐amplifying RNA and mitigates its immunogenicity

FEBS Open Bio, EarlyView.
ICP34.5 is one of the most important antihost response proteins. The saRNA‐encoding HSV‐1 neurovirulence protein ICP34.5 clearly mediated the eukaryotic initiation factor 2 alpha subunit (eIF2α) dephosphorylation and significant suppression of innate immune responses in vitro, leading to enhanced expression of the saRNA‐encoded gene.
Xuemin Lu, Yabin Wu, Chunye Zhao, Jie Zheng, Shangwu Chen, Yigang Wang, Yulong Xia   +6 more
wiley   +1 more source

Designing a novel in-silico multi-epitope vaccine against penicillin-binding protein 2A in Staphylococcus aureus

Informatics in Medicine Unlocked, 2022
Research has shown the implication of Penicillin-Binding Protein 2A (PBP2A) as a critical factor in Methicillin-Resistant Staphylococcus aureus (MRSA) as it confers resistance to β‐lactam antibiotics on S.
Simeon Kayowa Olatunde, Elijah Kolawole Oladipo, Joshua Babatunde Owolabi   +2 more
doaj  

Development of a Human Cytomegalovirus (HCMV)-Based Therapeutic Cancer Vaccine Uncovers a Previously Unsuspected Viral Block of MHC Class I Antigen Presentation [PDF]

, 2019
Human cytomegalovirus (HCMV) induces a uniquely high frequency of virus-specific effector/memory CD8+ T-cells, a phenomenon termed “memory inflation”.
Abate, Ahmed, Alexandrov, Alexandrov, Arnon, Avdic, Beyranvand Nejad, Brown, Brown, Browne, Chang, Chu, Cloughesy, Cobbs, Dasari, Dekhtiarenko, Del Val, Desjardins, Doisne, Dos Santos, Draper, Duhen, Dziurzynski, Engels, Fiallos, Filley, Fruh, Galluzzi, Gilbert, Gorzer, Harkins, Heemskerk, Howland, Jarry, Johnson, Jutz, Jutz, Kern, Klenerman, Korn, Kotenko, Lauvau, Le, Leisegang, Lim, Lockridge, Locy, Louveau, Lucas, Luo, Malouli, Martikainen, Mitchell, Mocarski, Nair, Neefjes, Odeberg, Overwijk, Pardieck, Polyzoidis, Potter, Prins, Pule, Raftery, Raftery, Raftery, Raftery, Rahman, Ratzinger, Reap, Reardon, Reed, Ressing, Riegler, Rizvi, Rosato, Rosskopf, Sampaio, Sampson, Sandalova, Schempp, Scheper, Schmolke, Schneider, Schonrich, Schub, Sckisel, Shah, Simoni, Sinzger, Soroceanu, Soroceanu, Strang, Stupp, Sturm, Sugawara, Sylwester, Thomas, Tischer, Tran, Trgovcich, Tumeh, van der Burg, van Willigen, Varnum, Vlahovic, Wen, Wills, Yan, Zhao   +109 more
core   +1 more source

SARS‐CoV‐2 Is Linked to Brain Volume Loss in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The impact of SARS‐CoV‐2 infection on brain and spinal cord pathology in patients with multiple sclerosis (pwMS) remains unclear. We aimed to describe changes in brain lesion activity and brain and spinal cord volumes following SARS‐CoV‐2 infection.
Tomas Uher, Dominika Stastna, Ingrid Menkyova, Vaclav Capek, Jiri Lindner, Petra Nytrova, Jan Krasensky, Eliza Varju, Miguel D'haeseleer, Eva Kubala Havrdova, Dana Horakova, Manuela Vaneckova, Niels Bergsland   +12 more
wiley   +1 more source

Employing an immunoinformatics approach revealed potent multi-epitope based subunit vaccine for lymphocytic choriomeningitis virus

Journal of Infection and Public Health, 2023
Background: Lymphocytic choriomeningitis virus (LCMV) infects many individuals worldwide and causes severe infection in the immunosuppressant recipient, spontaneous abortion, and congenital disabilities in infants.
Muhammad Waqas, Shahkaar Aziz, Aiman Bushra, Sobia Ahsan Halim, Amjad Ali, Saeed Ullah, Asaad Khalid, Ashraf N. Abdalla, Ajmal Khan, Ahmed Al-Harrasi   +9 more
doaj  

Synthetic B-Cell Epitopes Eliciting Cross-Neutralizing Antibodies: Strategies for Future Dengue Vaccine.

PLoS ONE, 2016
Dengue virus (DENV) is a major public health threat worldwide. A key element in protection from dengue fever is the neutralising antibody response. Anti-dengue IgG purified from DENV-2 infected human sera showed reactivity against several peptides when ...
Babu Ramanathan, Chit Laa Poh, Kristin Kirk, William John Hannan McBride, John Aaskov, Lara Grollo   +5 more
doaj   +1 more source

A multi-epitope vaccine GILE against Echinococcus Multilocularis infection in mice

Frontiers in Immunology, 2023
IntroductionThe objective of this study is to construct a multi-epitope vaccine GILE containing B-cell and T-cell epitopes against Echinococcus Multilocularis (E. multilocularis) infection based on the dominant epitopes of E. multilocularis EMY162, LAP, and GLUT1.MethodsThe structure and hydrophobicity of GILE were predicted by SWISSMODEL, pyMOL, SOPMA
Pei Zhou, Pei Zhou, Zhen Zhou, Meiduo Huayu, Lei Wang, Lin Feng, Lin Feng, Yang Xiao, Yang Xiao, Yao Dai, Yao Dai, Mingyuan Xin, Feng Tang, Runle Li, Runle Li   +14 more
openaire   +3 more sources