Results 81 to 90 of about 36,032 (319)

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source

Systems approach to design multi-epitopic peptide vaccine candidate against fowl adenovirus structural proteins for Gallus gallus domesticus

Frontiers in Cellular and Infection Microbiology
IntroductionFowl adenovirus (FAdV) is a significant pathogen in poultry, causing various diseases such as hepatitis-hydropericardium, inclusion body hepatitis, and gizzard erosion.
Susithra Priyadarhni Mugunthan, Divyadharshini Venkatesan, Chandramohan Govindasamy, Dhivya Selvaraj, Mani Chandra Harish   +4 more
doaj   +1 more source

Chagas Disease Diagnostic Applications: Present Knowledge and Future Steps [PDF]

, 2016
Chagas disease, caused by the protozoan Trypanosoma cruzi, is a lifelong and debilitating illness of major significance throughout Latin America and an emergent threat to global public health.
Balouz, Virginia, Buscaglia, Carlos Andres, Fernandez Aguero, Maria Jose   +2 more
core   +1 more source

Electric Pulse Regulated MXene Based Nanozymes for Integrative Bioelectricity Immuno‐Cancer Therapy

Advanced Functional Materials, EarlyView.
MXenzyme‐mediated bioelectricity cancer therapy (MXenzyme‐BECT) enhances cancer cell death through irreversible depolarization, ion channel disruption, ROS generation, and immunogenic cell death. Computational simulations reveal the electrical mechanisms by which MXenzyme acts on single cells and support to predict treatment parameters. Next‐generation
Sanghee Lee, Seongchan Kim, Eui‐Sang Yu, Sian Lee, Min Jun Ko, Hyojin Lee, Dong‐Hyun Kim   +6 more
wiley   +1 more source

In silico analysis for the development of multi-epitope vaccines against Mycobacterium tuberculosis

Frontiers in Immunology
As Bacille Calmette-Guérin (BCG) vaccine’s effectiveness is limited to only children, the development of new tuberculosis (TB) vaccines is being studied using several platforms, and a novel TB vaccine that overcomes this limitation is required.
Jin-Seung Yun, Jin-Seung Yun, A Reum Kim, Soo Min Kim, Eunkyung Shin, Sang-Jun Ha, Dokeun Kim, Hye-Sook Jeong   +7 more
doaj   +1 more source

Immunoinformatics-Aided Analysis of RSV Fusion and Attachment Glycoproteins to Design a Potent Multi-Epitope Vaccine

Vaccines, 2022
Respiratory syncytial virus (RSV) usually causes respiratory tract infections of upper airways in infants and young children. Despite recent medical advances, no approved vaccine is available to control RSV infections.
Hamza Arshad Dar, Fahad Nasser Almajhdi, Shahkaar Aziz, Yasir Waheed   +3 more
doaj   +1 more source

Stalking influenza by vaccination with pre-fusion headless HA mini-stem. [PDF]

, 2016
Inaccuracies in prediction of circulating viral strain genotypes and the possibility of novel reassortants causing a pandemic outbreak necessitate the development of an anti-influenza vaccine with increased breadth of protection and potential for rapid ...
A Schneemann, AH Ellebedy, C Ganesh, CJ Wei, D Corti, D Sharma, DC Ekiert, DC Ekiert, DG Higgins, DJ DiLillo, DT O’Hagan, F Ferrara, F Krammer, F Krammer, G Bommakanti, G Bommakanti, J Stevens, J Sui, JJ Skehel, JJ Skehel, JR Whittle, MB Mazanec, NJ Temperton, PH Goff, RD de Vries, S Guthe, S Jegaskanda, S Khurana, SA Valkenburg, TJ Wohlbold, U Rathore, VV Mallajosyula, VV Mallajosyula, W Gerhard, Y Huang, Y Wu   +35 more
core   +2 more sources

Intraoral Drug Delivery: Bridging the Gap Between Academic Research and Industrial Innovations

Advanced Functional Materials, EarlyView.
Intraoral drug delivery offers a promising route for systemic and localized therapies, yet challenges such as enzymatic degradation, limited permeability, and microbial interactions hinder efficacy. This figure highlights innovative strategies—mucoadhesive materials, enzyme inhibitors, and permeation enhancers—to overcome these barriers.
Soheil Haddadzadegan, Simona Summonte, Fabrizio Ricci, Matthias Sandmeier, Andreas Bernkop‐Schnürch   +4 more
wiley   +1 more source

Design of a Multi-epitope Peptide Vaccine against SARS-CoV-2 based on Immunoinformatics Data

Journal of Mazandaran University of Medical Sciences, 2020
Background and purpose: In 2019, the world has witnessed the emergence of a virus that caused acute respiratory distress syndrome in human with high mortality rates (approximately 3.7%).
Alireza Habibi, Amin Azizan, Yahya Ehteshaminia, Farhad Jadidi-Niaragh, Ehsan Enderami, Esmaeil Akbari, Saeid Abediankenari, Hadi Hassannia   +7 more
doaj  

Patent Landscape of Influenza A Virus Prophylactic Vaccines and Related Technologies [PDF]

, 2012
Executive Summary: This report focuses on patent landscape analysis of technologies related to prophylactic vaccines targeting pandemic strains of influenza.
Barton, Jeremy, Cavicchi, Jon R., Janovetz, Jeffrey, Kowalski, Stanley P., Pflugh, David L., Schroeder, John   +5 more
core   +1 more source