Results 111 to 120 of about 5,820,721 (304)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
, 2017 The concept of "small is beautiful" espoused by British economist EF Schumacher came to mind when referring to the Mid and Small Cap (MidS) Research Scheme that was jointly unveiled by Bursa Malaysia and the Securities Commission ...
Focus, Malaysia
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Multi-focus fractal-graph networks
Journal of the Franklin Institute, 1991 Abstract We introduce the notion of multi-focus fractal-graph networks which are used to characterize large dynamic telecommunication, computer and data networks. These networks are synthesized using recently developed concepts of fractal geometry and are characterized by a fractal dimension, more than one central node and a large number of auxiliary
Dwight L. Jaggard +2 more
openaire +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Annual Report (Focus on the Global South 2013
, 2013 Focus on the Global South was established in 1995 to challenge neoliberalism, militarism and corporate-driven globalization while strengthening just and equitable alternatives. We work in solidarity with the Global South – the great majority of humanity
Focus on the Global South (Program)
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Image Segmentation-Based Multi-Focus Image Fusion Through Multi-Scale Convolutional Neural Network
IEEE Access, 2017 A decision map contains complete and clear information about the image to be fused, and detecting the decision map is crucial to various image fusion issues, especially multi-focus image fusion.
Chaoben Du, Shesheng Gao
doaj +1 more source
Multi-focus plasmonic lens design based on holography
Optics Express, 2013 Multi-focus plasmonic lens with metallic nanoslits of variant widths have great potential applications in optical interconnection, integrated optics and nanophotonics. But the design method with simulated annealing algorithm or Yang-Gu algorithm requires complex calculation and multi focuses are limited to be set on the same output plane. In this paper,
Hui, Pang +5 more
openaire +2 more sources
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
, 1998 This report provides highlights and delegate feedback from Greater Easterhouse Multi-Agency Domestic Violence Forum conference held September 1998. This brought together over 60 delegates from key agencies, representing a spread of senior managers and ...
Greater Easterhouse Multi-Agency Domestic Violence Forum
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Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source