Results 111 to 120 of about 8,371,948 (295)
Image Segmentation-Based Multi-Focus Image Fusion Through Multi-Scale Convolutional Neural Network
IEEE Access, 2017 A decision map contains complete and clear information about the image to be fused, and detecting the decision map is crucial to various image fusion issues, especially multi-focus image fusion.
Chaoben Du, Shesheng Gao
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Annual Report (Focus on the Global South
, 2004 Focus on the Global South was established in 1995 to challenge neoliberalism, militarism and corporate-driven globalization while strengthening just and equitable alternatives. We work in solidarity with the Global South – the great majority of humanity
Focus on the Global South (Program)
core
, 2008 This paper reviews notions related to focus and presupposition and addresses the hypothesis that focus triggers an existential presupposition. Presupposition projection behavior in certain examples appears to favor a presuppositional analysis of focus ...
Abusch, Dorit, Dorit Abusch
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Annual Report (Focus on the Global South 2013
, 2013 Focus on the Global South was established in 1995 to challenge neoliberalism, militarism and corporate-driven globalization while strengthening just and equitable alternatives. We work in solidarity with the Global South – the great majority of humanity
Focus on the Global South (Program)
core
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source