Results 111 to 120 of about 12,444,642 (294)

Governing Integration Policies in a Multi-Level Setting: Austria and Czechia Compared

Central and Eastern European Migration Review
In migration studies, scholars differ in their emphasis on which level of government plays the central role in immigrant integration policies. There are voices drawing attention to a ‘local turn’, highlighting the rising power of local actors in ...
Anna Lukešová
doaj   +1 more source

COMBINING MULTI-LEVEL AND NETWORK GOVERNANCE WITH A SPILLOVER EFFECT: THE CASE OF THE EUROPEAN “INNOVATION UNION” FLAGSHIP INITIATIVE [PDF]

Challenges of the Knowledge Society, 2011
The purpose of this paper is to demonstrate the possibility of a theoretical up-grade to the framework offered by the theory of governance: from a middle-range theory to a full theory through adding a neofunctionalist component that would enhance its ...
OANA-ANDREEA ION, IOANA DODI, ANDRA POPA
doaj  

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Local and global in the governing process: a complex phenomenon

Sfera Politicii, 2015
In the context of intensive globalization, scientific research in the field of social sciences proposes an explanatory multi- level perspective of the studied phenomena. A key concept belonging to political sciences, yet trans-disciplinarily, is that of „
Emilia‑Elena Clucerescu (Tănase)
doaj  

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

EU transport infrastructure policy, new institutionalism and types of multi-level governance : the cases of Vienna and London [PDF]

The European integration process has fundamentally changed the system of governing in Europe. No longer is European governance confined to the nation-state level, but rather involves a variety of supranational, national and sub-national actors.
Awesti, Anil
core  

Framework of government big data governance system and effective way of implementation

大数据, 2019
Limited by single disciplinary perspective from disparate aspects at different levels,there is lack of systematic study on big data governance system building in current literature.A systematic review of literature and case studies under ...
Xiaomi AN, Mingjun GUO, Xuehai HONG, Wei WEI   +3 more
doaj  

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source