Results 91 to 100 of about 13,022,574 (257)
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
The Economy Governing During Globalization Era [PDF]
Theoretical and Applied Economics, 2006 World and national economie governing is an essential premise of the political stability and democratic evolution. In this study are approached theoretical and practical aspects of the economie governing.
Ion Bucur
doaj +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Political Disagreement and Delegation in a Multi-Level Governance Setting [PDF]
A large share of delegation models takes into account the effect of political disagreement when explaining delegation. Yet, delegation models make sharply contrasting predictions on how political disagreement translates into the level of discretion ...
Diane Payne +2 more
core
European Journal of Spatial DevelopmentThis article argues that a crucial step towards a more nuanced understanding of civil society conflicts surrounding the mobility transition is the adoption of a spatial perspective, which considers the navigation of the involved levels of governance. To
Anna Loffing, Meike Levin-Keitel
doaj +1 more source
SOME ASPECTS REGARDING REGIONALIZATION IN THE EUROPEAN UNION [PDF]
Strategii Manageriale, 2014 Regional development policies initiated in the last decades, European countries, aimed at recovery economic and social development locally, economic recovery less developed areas, reducing disparities between the levels of development of the regions.
Ion, POPESCU, Cosmin-Ionut, ENESCU
doaj
Unpacking multi-level governance of antimicrobial resistance policies: the case of Guangdong, China. [PDF]
Health Policy Plan, 2022 Chan OSK +8 more
europepmc +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Von Environmental Governance zu Landscape Governance: Multi-Level-Governance und Politics of Scale [PDF]
Governance has definitely become a very iridescent concept in recent years. The term is widely used, meanwhile, in almost all social-science disciplines as well as in the political process.
Görg, Christoph
core
A multi-level governance response to the Covid-19 crisis in public transport. [PDF]
Transp Policy (Oxf), 2021 Hirschhorn F.
europepmc +1 more source