Results 81 to 90 of about 13,022,574 (257)

Multi-level governance and adaptive capacity in West Africa

open access: yesInternational Journal of the Commons, 2012
In most regions in West Africa, livelihoods depend heavily on forest ecosystem goods and services, often in interplay with agricultural and livestock production systems. Numerous drivers of change are creating a range of fundamental economic, ecological,
Maria Brockhaus   +2 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Multi-level Governance and Security: The Security Sector Reform Process in the Central African Republic [PDF]

open access: yes
Analysing how the SSR process in CAR has been defined and then implemented, this article puts emphasis on the international interactions between institutional actors who may be geographically/territorially situated at different levels of the policy ...
Niagalé Bagayoko-Penone
core  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Emergența modelului guvernanței multi-level în România

open access: yesRevista Transilvană de Ştiinţe Administrative, 2009
The communitarian model of Multi-Level Governance has become the EU model of territorial policies governance. This paper aims to show that the characteristics of the Multi-Level Governance model are currently emerging in Romania.
Constantin CHIRIAC
doaj  

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

open access: yesMolecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic   +15 more
wiley   +1 more source

Legitimacy analysis of multi-level governance of biodiversity: Evidence from 12 case studies across the EU [PDF]

open access: yes
Legitimacy is regarded as one critical aspect of biodiversity management and nature conservation arrangements. Multi-level governance is claimed to pose several challenges to legitimacy.
Suéskeviécs, Monika
core  

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Multi-level Governance: The General Model and the Italian Experience [PDF]

open access: yes
During the last twenty years, the introduction of the principle of subsidiarity and the identification of regions as political entities for the coordination of structural expenditure at the local level have led to the adoption of the principle of multi ...
Zampino, Simona, Bagarani, Massimo
core  

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