Results 71 to 80 of about 159,405 (302)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Multi-level Governance and Security: The Security Sector Reform Process in the Central African Republic [PDF]

open access: yes
Analysing how the SSR process in CAR has been defined and then implemented, this article puts emphasis on the international interactions between institutional actors who may be geographically/territorially situated at different levels of the policy ...
Niagalé Bagayoko-Penone
core  

Multi-stakeholder collaboration in Russian and Swedish model forest initiatives : adaptive governance toward sustainable forest management? [PDF]

open access: yes, 2010
Building the adaptive capacity of interlinked social and ecological systems is assumed to improve implementation of sustainable forest management (SFM) policies.
Angelstam, Per   +11 more
core   +1 more source

Locating Cities and Their Governments in Multi-Level Sustainability Governance

open access: yes, 2021
Cities and their governments are increasingly recognized as important actors in global sustainability governance. With the adoption of the 2030 Agenda for Sustainable Development, their role in the global endeavor to foster sustainability has once again ...
Global Sustainability Governance   +2 more
core   +1 more source

Emergența modelului guvernanței multi-level în România

open access: yesRevista Transilvană de Ştiinţe Administrative, 2009
The communitarian model of Multi-Level Governance has become the EU model of territorial policies governance. This paper aims to show that the characteristics of the Multi-Level Governance model are currently emerging in Romania.
Constantin CHIRIAC
doaj  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Legitimacy analysis of multi-level governance of biodiversity: Evidence from 12 case studies across the EU [PDF]

open access: yes
Legitimacy is regarded as one critical aspect of biodiversity management and nature conservation arrangements. Multi-level governance is claimed to pose several challenges to legitimacy.
Suéskeviécs, Monika
core  

Natural resource management as a form of multi-level governance: the impact of reform in Queensland and Tasmania

open access: yes, 2017
[Extract] Australia’s multi-level system for the governance of natural resources has changed significantly in the last 40 years. In this context, we refer to multiple levels of governance across spatial scales (as per Cash et al.2006).
Ryan, Sarah   +5 more
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

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