Results 61 to 70 of about 159,405 (302)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Environmental governance: Participatory, multi-level - and effective? [PDF]

open access: yes
Current international and European Union environmental policies increasingly promote collaborative and participatory decision-making on appropriate and multiple governance levels as a means to attain more sustainable policies and a more effective and ...
Fritsch, Oliver, Newig, Jens
core  

Multi- Level Governance Framework for Global Political Renewal

open access: yes, 2023
The Global Council for Political Renewal has a diverse and esteemed group of political leaders from around the world. With an outstanding lineup of speakers in the conference, including government ministers, MPs, Nobel Peace Prize laureates, ambassadors ...
Ajeeb, D.
core  

THE MULTI-LEVEL GOVERNANCE OF INTERNATIONAL MIGRATION

open access: yesМодернизация, инновация, развитие, 2015
Article retractedThe article provides the history of legal framework of regulating migration processes on the global level. The author analyzes the dual nature of migration policy on the regional, national and global levels, which occurs when interests ...
Ivan A. Aleshkovskii
doaj  

Next level? Civil society’s navigation of multi-level governance in the conflict over cycling conditions in Bavaria

open access: yesEuropean Journal of Spatial Development
This article argues that a crucial step towards a more nuanced understanding of civil society conflicts surrounding the mobility transition is the adoption of a spatial perspective, which considers the navigation of the involved levels of governance. To
Anna Loffing, Meike Levin-Keitel
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

open access: yesMolecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht   +3 more
wiley   +1 more source

IMPLICATIONS OF THE EU MULTI-LEVEL GOVERNANCE IN THE FIELD OF COMPETITION POLICY – A COMPARATIVE ANALYSIS OF THE CHARACTERISTICS OF COHESION AND COMPETITION POLICY [PDF]

open access: yes
The paper has in view to present the intrinsic characteristics of the European Union and to show that these characteristics require in an objective way the implementation of a multi-level governance.
Florin Bonciu
core  

Multi-level Governance in Environmental Risk Management

open access: yesOñati Socio-Legal Series, 2011
The article examines regulatory strategies in the field of ecological disaster management with reference to the sociology of risk. The risk perspective draws attention to the fact that political strategies of regulation are to be understood as processes
Petra Hiller
doaj  

Multi-level governance and adaptive capacity in West Africa

open access: yesInternational Journal of the Commons, 2012
In most regions in West Africa, livelihoods depend heavily on forest ecosystem goods and services, often in interplay with agricultural and livestock production systems. Numerous drivers of change are creating a range of fundamental economic, ecological,
Maria Brockhaus   +2 more
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

open access: yesMolecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski   +12 more
wiley   +1 more source

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