From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Governance system construction for China’s metropolitan regions based on rescaling and multi-level governance: A case study of the Nanjing Metropolitan Region [PDF]
Ziyuan Kexue[Objective] Exploring the construction logic of China’s metropolitan regions governance system is conducive to enriching and deepening the research of “city-region” governance mechanism, and providing a scientific basis for promoting the optimisation of ...
YU Jie, LI Luqi, LV Ligang, ZHU Junjun, ZHAO Wei, CHEN Pinyu
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Unraveling the Central State, But How? Types of Multi-Level Governance. IHS Political Science Series: 2003, No. 87 [PDF]
, 2003 The reallocation of authority upwards, downwards, and sideways from central states has drawn attention from a growing number of scholars in political science.
Marks, Gary, Hooghe, Liesbet
core
Levels, scales, linkages, and other 'multiples' affecting natural resources
International Journal of the Commons, 2012 Natural resources are affected by several types of “multiples.” Some analysts emphasize linkages across multiple scales while others focus on interactions across multi-level institutions or multiple fields of action.
Amy R. Poteete
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Conceptual approaches and features of multi-level governance in eu countries: experience for Ukraine
Theory and Practice of Public AdministrationThe article analyzes the conceptual approaches and features of multilevel governance. The main attention is focused on the applied aspects of multilevel governance based on the experience of EU countries, as well as identifying opportunities for its ...
Valentyn Suvorov
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Position of OLAF in a multi-level governance system of the European Union [PDF]
Przegląd Europejski, 2019 The author aims to investigate the position of OLAF in the multi-level governance system (MLG) of the European Union with specific inter-institutional consequences of such location, assuming that OLAF is not a classical supranational institution.
Janusz Ruszkowski
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source