Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Unraveling the Central State, But How? Types of Multi-Level Governance. IHS Political Science Series: 2003, No. 87 [PDF]
, 2003 The reallocation of authority upwards, downwards, and sideways from central states has drawn attention from a growing number of scholars in political science.
Marks, Gary, Hooghe, Liesbet
core
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Multi-stakeholder collaboration in Russian and Swedish model forest initiatives : adaptive governance toward sustainable forest management? [PDF]
, 2010 Building the adaptive capacity of interlinked social and ecological systems is assumed to improve implementation of sustainable forest management (SFM) policies.
Angelstam, Per +11 more
core +2 more sources
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
EU Transport Infrastructure Policy, New Institutionalism and Types of Multi-Level Governance: The Case of Vienna [PDF]
, 2009 Multi-level Governance (MLG) fundamentally challenges a state-centric, intergovernmentalist understanding of EU policy-making, emphasising the nonhierarchical, interconnected and multi-actor nature of contemporary governing.
Awesti, Anil
core
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Transylvanian Review of Administrative Sciences, 2017 Over the past two decades, the concept ofmulti-level governance (MLG) has been increasinglydiscussed by scholars in the fi eld of Europeanintegration.
Vratislav HAVLÍK, Petra KUCHYŇKOVÁ
doaj +1 more source
Drought governance: A cross-level governance analysis in Botswana
Climate Risk Management, 2023 Drought, a growing climate change hazard, is a multilevel problem that affects and is affected by decisions that are made at multiple levels of governance (local, district, and national).
Kulthoum Omari Motsumi +2 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source