Results 51 to 60 of about 13,022,574 (257)

Types of Multi-Level Governance [PDF]

open access: yes
The reallocation of authority upwards, downwards, and sideways from central states hasdrawn attention from a growing number of scholars in the social sciences.
Liesbet Hooghe, Gary Marks
core   +1 more source

Multi-level governance application to a shared river basin

open access: yesRBRH, 2020
Water governance systems must be effective in establishing policies capable of guiding decision making. Their framework needs to weigh the intrinsic complexity of inter-scale and multi-level interactions.
Wanessa Dunga de Assis   +2 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Developing Adaptation Policy and Practice in Europe: Multi-level Governance of Climate Change

open access: yes, 2010
Although mitigation of climate change dominates the climate change agenda in Finland, adaptation to climate change is increasingly recognised as an important policy issue across all levels of governance Finland was an early mover on adaptation, being the
Juhola, Sirkku,   +7 more
core   +2 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

Five dimensions of climate governance: a framework for empirical research based on polycentric and multi‐level governance perspectives [PDF]

open access: yes, 2021
Governance of climate mitigation and adaptation has been discussed within polycentric and multi‐level governance perspectives. Both perspectives on climate governance are intimately related but yet in some regards are distinctly different ‐ as one ...
Alessandro Arlati   +5 more
core   +1 more source

Conceptual approaches and features of multi-level governance in eu countries: experience for Ukraine

open access: yesTheory and Practice of Public Administration
The article analyzes the conceptual approaches and features of multilevel governance. The main attention is focused on the applied aspects of multilevel governance based on the experience of EU countries, as well as identifying opportunities for its ...
Valentyn Suvorov
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

open access: yesFEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Governance system construction for China’s metropolitan regions based on rescaling and multi-level governance: A case study of the Nanjing Metropolitan Region [PDF]

open access: yesZiyuan Kexue
[Objective] Exploring the construction logic of China’s metropolitan regions governance system is conducive to enriching and deepening the research of “city-region” governance mechanism, and providing a scientific basis for promoting the optimisation of ...
YU Jie, LI Luqi, LV Ligang, ZHU Junjun, ZHAO Wei, CHEN Pinyu
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

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