Results 101 to 110 of about 12,444,642 (294)

Implications of the EU Multi-Level Governance in the Field of Competition Policy – A Comparative Analysis of the Characteristics of Cohesion and Competition Policies [PDF]

open access: yesRomanian Journal of European Affairs, 2011
The paper aims at analyzing the intrinsic characteristics of the European Union and to show that these characteristics objectively require the implementation of multi-level governance.
Florin Bonciu
doaj  

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

open access: yesMolecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas   +16 more
wiley   +1 more source

Spatial biology in cancer epigenetics

open access: yesMolecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

THE ROMANIAN ASPECT OF THE E.U. GOVERNANCE CASE STUDIES: EDUCATUION POLICY AND ENVIRONMENTAL POLICY [PDF]

open access: yesChallenges of the Knowledge Society, 2011
This paper belongs to the domestic studies which try to connect the Romanian research to the current debates within the EU studies. The authors' aim is to analyze the aspects and the implications of the EU governance at the Member States' domestic ...
OANA-ANDREEA ION   +2 more
doaj  

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

Natural resource management as a form of multi-level governance: the impact of reform in Queensland and Tasmania

open access: yes, 2017
[Extract] Australia’s multi-level system for the governance of natural resources has changed significantly in the last 40 years. In this context, we refer to multiple levels of governance across spatial scales (as per Cash et al.2006).
Ryan, Sarah   +5 more
core   +1 more source

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