Results 71 to 80 of about 2,369,874 (297)

Performance measurement systems, TQM, and multi-level firm performance: a person-organisation fit perspective [PDF]

, 2017
For firms implementing TQM, there is a need to redesign performance measurement systems (PMS). Innovated PMS ought to have measurement diversity in their structure with considering the spirit of TQM and emphasize the congruence of goals between ...
Anderson S. W., Commonwealth, Edwards J. R., Fowler F. J., Hassan M. U., Hsin-Hung Wu, Jo-Ting Wei, Kaplan R. S., Kaur P., Wayhan S. H., Xiaoxiang Zhang, Yeun Wen Chang, Yung-Tai Tang   +12 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Connecting Levels of Analysis in Educational Neuroscience: A Review of Multi-level Structure of Educational Neuroscience with Concrete Examples [PDF]

, 2019
In its origins educational neuroscience has started as an endeavor to discuss implications of neuroscience studies for education. However, it is now on its way to become a transdisciplinary field, incorporating findings, theoretical frameworks and ...
Han, Hyemin
core  

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

A heuristic framework to portray agroecological transition initiatives in reflexive arrangements, illustrated with a conservation agriculture network in Denmark

Ecology and Society
Agroecology has been proposed as an answer to the current global agri-food system crises. Transformation to agroecological agri-food systems can be enhanced through collaboration between societal agroecological initiatives and scientists in reflexive ...
Pauline Cassart, Anina Frei, Henrik Hauggaard-Nielsen, Henrik Kruse Rasmussen, Adrien Swartebroeckx, Eric Froidmont, Didier Stilmant, Walter A. H. Rossing   +7 more
doaj   +1 more source

Faceted Views of Varying Emphasis (FaVVEs): a framework for visualising multi-perspective small multiples [PDF]

, 2016
Many datasets have multiple perspectives – for example space, time and description – and often analysts are required to study these multiple perspectives concurrently.
Andrienko, Bartram, Bederson, Brunsdon, Brunsdon, Butkiewicz, Cleveland, Cohen, Ellis, Elmqvist, Gleicher, Harrower, Hummel, Javed, Lam, Munzner, O'sULLIVAN, Roth, Schnall, UPTON, Wang Baldonado, Yuill   +21 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Intelligent protocol adaptation for enhanced medical e-collaboration [PDF]

, 2003
Copyright @ 2003 AAAIDistributed multimedia e-health applications have a set specific requirements which must be taken into account effective use is to be made of the limited resources provided by public telecommunication networks.
Frank, AO, Ghinea, G, Magoulas, GD
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source