Results 91 to 100 of about 774,946 (268)
Multi objective elk herd optimization for efficient structural design
Scientific ReportsThis research presents an advancement of the Elk Herd Optimization targeting specific real-world multi-objective optimization problems, this algorithm is stated as the multi-objective Elk Herd Optimization (MOEHO).
Pinank Patel +7 more
doaj +1 more source
Dynamic Weights in Multi-Objective Deep Reinforcement Learning
, 2019 Many real-world decision problems are characterized by multiple conflicting objectives which must be balanced based on their relative importance. In the dynamic weights setting the relative importance changes over time and specialized algorithms that ...
Abels, Axel +4 more
core +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Solving multi-objective hub location problems by hybrid algorithms [PDF]
, 2018 In many logistic, telecommunications and computer networks, direct routing of commodities between any origin and destination is not viable due to economic and technolog- ical constraints.
Chicano, Francisco +3 more
core
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
An Investigation of Hybrid Framework for Dynamic Multi Objective Problems
Gazi Üniversitesi Fen Bilimleri Dergisi, 2018 Multi-objective evolutionary algorithms and selection hyper-heuristics are adaptive methods that can handle different types of dynamism which may occur in the environment.
Berna KİRAZ
doaj +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Solving Flexible Job Shop Scheduling with Multi Objective Approach
International Journal of Industrial Engineering and Production Research, 2010 In this paper flexible job-shop scheduling problem (FJSP) is studied in the case of optimizing different contradictory objectives consisting of: (1) minimizing makespan, (2) minimizing total workload, and (3) minimizing workload of the most loaded ...
Arash Motaghedi-larijani +2 more
doaj
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source