Results 41 to 50 of about 25,230 (292)

Multi-objective fuzzy modeling of project scheduling with limitations of multi-skilled resources able to change skill levels and interrupt activities [PDF]

open access: yesInternational Journal of Industrial Engineering and Production Research, 2021
Project scheduling is one of the most important and applicable concepts of project management. Many project-oriented companies and organizations apply variable cost reduction strategies in project implementation.
Mojtaba Salehi, Efat Jabarpoor
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Goal programming associated with the non-archimedean infinitesimal: a case study applied in the agricultural sector

open access: yesProduction, 2021
Paper aims This work presents a multi-objective method based on goal programming associated with non-Archimedean infinitesimal (NAI) (Improved Weighted Goal Programming method, input-oriented IWGP-MCDEA-BCC).
Fabiana Gomes dos Passos   +2 more
doaj   +1 more source

Multi item inventory model include lead time with demand dependent production cost and set-up-cost in fuzzy environment [PDF]

open access: yesJournal of Fuzzy Extension and Applications, 2020
In this paper, we have developed the multi-item inventory model in the fuzzy environment. Here we considered the demand rate is constant and production cost is dependent on the demand rate.
Satya Das
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

Spatial biology in cancer epigenetics

open access: yesMolecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Screening Routine Clinical Notes for Epilepsy Surgery Candidates Using Large Language Models

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epilepsy surgery is severely underutilized despite proven efficacy, with substantial under‐referral of eligible patients in routine clinical practice. This study evaluated the potential role of large language models (LLMs) as decision‐support tools for screening unstructured clinical notes to identify epilepsy surgery candidates and ...
Uriel Fennig   +9 more
wiley   +1 more source

The Price of Precision: A Critical Review of Molecular Diagnostics in Glioma, From Guidelines to Global Disparities

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Gliomas have undergone a profound redefinition over the past decade, transitioning from morphology‐based entities to biologically coherent diseases defined by molecular alterations. The 2021 WHO Classification of Tumors of the Central Nervous System and its 2022 update formalize this shift, establishing integrated diagnosis as the global ...
Maria Guarnaccia, Sebastiano Cavallaro
wiley   +1 more source

Fuzzy Goal Programming Approach in Vehicle Routing Problem

open access: yesJournal of Transportation and Logistics, 2017
The goal programming is commonly used programming techniques in multi-objective decision making approaches. It is not possible to exactly determine the goals and constraints in real life problems.
Selen Çelikkanat filiz, Ergün Eroğlu
doaj   +1 more source

Robust Integrated Optimization for Green Closed Loop Supply Chain [PDF]

open access: yesچشم‌انداز مدیریت صنعتی, 2019
With increasing environmental pollution in recent years, researchers have focused on designing a closed loop supply chain network with consideration of environmental issues.
Saba Manouchehri   +2 more
doaj   +1 more source

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