Results 61 to 70 of about 872,112 (308)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Multi-Objective BiLevel Optimization by Bayesian Optimization

Algorithms
In a multi-objective optimization problem, a decision maker has more than one objective to optimize. In a bilevel optimization problem, there are the following two decision-makers in a hierarchy: a leader who makes the first decision and a follower who ...
Vedat Dogan, Steven Prestwich
doaj   +1 more source

Optimum Nozzle Design for a Viscous Liquid by Using Multi-Objective Search Approaches

IEEE Access, 2020
This work deals with the problem of a nozzle design addressed through a multi-objective optimization strategy where governing equations of fluid dynamics model the phenomena.
Victor Dario Cuervo Pinto, Alejandro Rodriguez-Molina, Leonel German Corona-Ramirez, Miguel Gabriel Villarreal-Cervantes   +3 more
doaj   +1 more source

Multi-Objective Mayfly Optimization in Phase Optimization of OFDM

International Islamic University Malaysia Engineering Journal, 2023
Communication systems have been used tremendously in recent years which results in the need for high data transmission rates. Orthogonal Frequency Division Multiplexing (OFDM) provides robust performance in frequency selective fading due to high ...
Abdul Azeez, Suraiya Tarannum
doaj   +1 more source

Adaptive Multi-objective Optimization for Energy Efficient Interference Coordination in Multi-Cell Networks [PDF]

, 2014
In this paper, we investigate the distributed power allocation for multi-cell OFDMA networks taking both energy efficiency and inter-cell interference (ICI) mitigation into account.
Fei, Zesong, Kuang, Jingming, Li, Na, Xing, Chengwen   +3 more
core  

Multi-Objective Digital Design Optimization via Improved Drive Granularity Standard Cells [PDF]

, 2021
Linan Cao, Simon J. Bale, Martin A. Trefzer   +2 more
openalex   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

A new multi objective crested porcupines optimization algorithm for solving optimization problems

Scientific Reports
This paper presents a new multi-objective optimization algorithm called the Multi-Objective Crested Porcupines Optimization (MOCPO) Algorithm, which uses an elitist, non-dominated sorting and crowding distance mechanism.
Divya Adalja, Pinank Patel, Nikunj Mashru, Pradeep Jangir, Arpita, Reena Jangid, G. Gulothungan, Mohammad Khishe   +7 more
doaj   +1 more source

A Multi Objective Optimization Approach for Resources Procurement of Bank [PDF]

Journal of Optimization in Industrial Engineering, 2010
Calculating total cast of bank resources procurement methods which include current -free loan deposit, saving interest-free loan deposit, regular and net short-term investment deposit, long-term investment deposit and surety bond cash deposit and ...
amir mohammad-zadeh, naser hamidi, mohammad amin nayebi, yusof ebrahimi-sajas   +3 more
doaj  

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source