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Editorial: Multi-omic data integration [PDF]
Frontiers in Cell and Developmental Biology, 2015 As researchers involved in molecular biology, we are witnessing tremendous paradigm changes in a time frame that becomes shorter and shorter. The epoch-making notion, originally put forward by the central dogma of biology (Crick, 1970), that there is a unidirectional process and a privileged level (genetic) of causality at which biological functions ...
Christine eNardini +3 more
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Towards a Multi-Omics of Male Infertility
The World Journal of Men's Health, 2023 Infertility is a common problem affecting one in six couples and in 30% of infertile couples, the male factor is a major cause. A large number of genes are involved in spermatogenesis and a significant proportion of male infertility phenotypes are of genetic origin.
Ana Ogrinc Wagner +2 more
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Omics and Multi-Omics in IBD: No Integration, No Breakthroughs [PDF]
, 2023 The recent advent of sophisticated technologies like sequencing and mass spectroscopy platforms combined with artificial intelligence-powered analytic tools has initiated a new era of “big data” research in various complex diseases of still ...
Claudio Fiocchi
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Multiple genetic analyses for Chinese Hunan Han population via 46 A-STRs
Annals of Human Biology, 2022 Background Short tandem repeats (STRs) are important as common genetic markers in forensic identification and population genetics due to their highly polymorphic nature.
Yunying Zhang +7 more
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Prioritization of schizophrenia risk genes from GWAS results by integrating multi-omics data [PDF]
, 2021 Schizophrenia (SCZ) is a polygenic disease with a heritability approaching 80%. Over 100 SCZ-related loci have so far been identified by genome-wide association studies (GWAS). However, the risk genes associated with these loci often remain unknown.
Qi, Mengling +11 more
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Multi-omics data integration through ConvGNN for COPD prediction. [PDF]
, 2023 The ConvGNN models were trained in a 4-fold CV strategy with two omics data: proteomics and transcriptomics. The STRING PPI network was used for graph convolution.
Fuyong Xing (6494963) +7 more
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Journal of Hematology & Oncology, 2020 Background Conventional therapeutic approaches for tumor angiogenesis, which are primarily focused on the inhibition of active angiogenesis to starve cancerous cells, target the vascular endothelial growth factor signaling pathway.
Young Sun Choi +10 more
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Microbial community succession in the intestine of mice with deep partial-thickness burns
Frontiers in Microbiology, 2023 IntroductionBurn injury has been shown to lead to changes in the composition of the gut microbiome and cause other damage in patients. However, little is known about how the gut microbial community evolves in individuals who have recovered from burn ...
Li-Jian Chen +14 more
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Harnessing Knowledge from Plant Functional Genomics and Multi-Omics for Genetic Improvement [PDF]
, 2023 Plant biology research has currently entered the post-genomics era with the advances in genomic technologies. The unprecedented development of genomics and application in crops is driving a new “green revolution” in agriculture.
G, Yang +4 more
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DeepInsight-3D architecture for anti-cancer drug response prediction with deep-learning on multi-omics [PDF]
, 2023 Modern oncology offers a wide range of treatments and therefore choosing the best option for particular patient is very important for optimal outcome.
Lysenko, Artem +3 more
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