Results 41 to 50 of about 2,476,048 (310)

Development and validation of a risk prediction model for overall survival in patients with nasopharyngeal carcinoma: a prospective cohort study in China

open access: yesCancer Cell International, 2022
Objective Nasopharyngeal carcinoma (NPC) is prevailing in Southern China, characterized by distinct geographical distribution. Aimed to predict the overall survival (OS) of patients with nasopharyngeal carcinoma, this study developed and validated ...
Siwei Miao   +7 more
doaj   +1 more source

New Advances, Challenges and Opportunities in Forensic Applications of Microbiomics

open access: yesFayixue Zazhi, 2022
The succession of microbiota is closely associated with several essential factors, including race, sex, health condition, lifestyle, postmortem interval, etc., and it has great potential application value in forensic medicine.
LEI Fan-zhang   +4 more
doaj   +1 more source

MoReL: Multi-omics Relational Learning

open access: yesCoRR, 2022
Multi-omics data analysis has the potential to discover hidden molecular interactions, revealing potential regulatory and/or signal transduction pathways for cellular processes of interest when studying life and disease systems. One of critical challenges when dealing with real-world multi-omics data is that they may manifest heterogeneous structures ...
Arman Hasanzadeh   +3 more
openaire   +3 more sources

Nicotinamide enhances osteoblast differentiation through activation of the mitochondrial antioxidant defense system

open access: yesExperimental and Molecular Medicine, 2023
Although the normal physiological level of oxidative stress is beneficial for maintaining bone homeostasis, imbalance between reactive oxygen species (ROS) production and antioxidant defense can cause various bone diseases.
Heein Yoon   +9 more
doaj   +1 more source

Structural Biology in the Multi-Omics Era [PDF]

open access: yesJournal of Chemical Information and Modeling, 2020
Rapid developments in cryogenic electron microscopy have opened new avenues to probe the structures of protein assemblies in their near native states. Recent studies have begun applying single -particle analysis to heterogeneous mixtures, revealing the potential of structural-omics approaches that combine the power of mass spectrometry and electron ...
Caitlyn L. McCafferty   +3 more
openaire   +2 more sources

Machine learning-driven multi-omics for optimizing biotherapeutic production [PDF]

open access: yes
Polson, Shawn W.Biotherapeutics, particularly monoclonal antibodies (mAbs) and recombinant adeno-associated viruses (rAAVs), have transformed the treatment landscape for various diseases.
Gurazada, Sai Guna Ranjan
core   +1 more source

Multi-Omics analysis identifies a lncRNA-related prognostic signature to predict bladder cancer recurrence [PDF]

open access: yes, 2021
Bladder cancer (BLCA) is one of the most common cancers worldwide with high recurrence rate. Hence, we intended to establish a recurrence-related long non-coding RNA (lncRNA) model of BLCA as a potential biomarker based on multi-omics analysis.
Zhipeng Xu (198453)   +5 more
core   +1 more source

Multi-Omics Journal Club [PDF]

open access: yes, 2023
Proceedings of the Multi-Omics Journal Club @ VCU "How many omics must a scientist sequence/ before you can call them a multi-omicist?" - Bob Dylan "hashtag Mo Omics Mo Problems" - HMW "Came for the knowledge, stayed for the sass" --EEL "Let's read ...
Eva Lancaster   +4 more
core   +2 more sources

An integrative multi-omics approach reveals new central nervous system pathway alterations in Alzheimer's disease [PDF]

open access: yes, 2021
Background Multiple pathophysiological processes have been described in Alzheimer's disease (AD). Their inter-individual variations, complex interrelations, and relevance for clinical manifestation and disease progression remain poorly understood.
Masoodi, Mojgan   +11 more
core   +1 more source

Gut microbiota from sigma-1 receptor knockout mice induces depression-like behaviors and modulates the cAMP/CREB/BDNF signaling pathway

open access: yesFrontiers in Microbiology, 2023
IntroductionDepression is a common mental disorder that affects approximately 350 million people worldwide. Much remains unknown about the molecular mechanisms underlying this complex disorder. Sigma-1 receptor (Sig-1R) is expressed at high levels in the
Jia-Hao Li   +8 more
doaj   +1 more source

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