Results 61 to 70 of about 3,539,790 (303)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Mechanisms of constipation alleviation by Lacticaseibacillus paracasei BGI-N2: insights from genes to phenotypes

BMC Microbiology
The global prevalence of constipation has been increasing in recent years, posing an urgent need for safer and more effective therapeutic strategies. Given the favorable safety profile and beneficial effects on gut health, probiotics have emerged as a ...
Xing Rao, Qiang Luo, Wanting Wei, Benliang Wei, Xinyu Yang, Yanhong Liu, Yangfeng Wen, Zhihui Ma, Zhinan Wu, Haifeng Zhang, Liang Xiao, Yiyi Zhong, Yuanqiang Zou   +12 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Dysfunction of the neurovascular unit as a temporal driver in Alzheimer’s pathogenesis

Translational Neurodegeneration
Extensive studies have shown that cerebrovascular dysfunction is a critical factor in the onset and progression of Alzheimer’s disease (AD). Neurovascular unit (NVU) is impaired in AD brains, including damage of tight junction between endothelial cells ...
Lifang Wang, Lei Han, Shiping Liu
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

The diagnostic value of plasma phosphorylated tau 181 in Alzheimer's disease within the Chinese population: A systematic review and meta-analysis

Journal of Alzheimer's Disease Reports
Background Among all related biomarkers, plasma phosphorylated tau (p-tau181) has demonstrated strong diagnostic performance in the very early stages of Alzheimer's disease (AD), showing significant differences between AD patients and healthy controls ...
Keqiang Yan, Haiyan Li, Shuxin He, Xiaodong Jia, Dequan Liu, Jianchun Chen   +5 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Genetic structure analysis of a Northwest Chinese population using a self-developed DIP system and machine learning for forensic ancestry inference

BMC Genomics
This study investigates forensic ancestry inference in admixed populations using a self-developed 60-DIP panel, analyzing Kyrgyz samples from Northwest China (CNK) and 26 reference populations from the 1000 Genomes Project.
Meiming Cai, Ruonan Shen, Xin Shi, Yiman Wu, Lisiteng Luo, Qinglin Liang, Bofeng Zhu   +6 more
doaj   +1 more source

Multi-omics in study of oral microbiome

Dental health and disease correlate with the ability of oral microbes to compose and perform their functions, along with interactions between constituent microorganisms inside the microbiota of the mouth.
Nguyen D.H., Chu D.-T.
core   +1 more source