Results 51 to 60 of about 3,539,790 (303)

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Multi-omics data integration through ConvGNN for COPD prediction.

, 2023
The ConvGNN models were trained in a 4-fold CV strategy with two omics data: proteomics and transcriptomics. The STRING PPI network was used for graph convolution.
Fuyong Xing (6494963), Katerina Kechris (436022), Craig P. Hersh (8543712), Brian D. Hobbs (5118383), Russell P. Bowler (275738), Farnoush Banaei-Kashani (5904845), Debashis Ghosh (32244), Yonghua Zhuang (11331069)   +7 more
core   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Multi-omics of AML [PDF]

, 2023
Acute myeloid leukemia (AML) is one of the most aggressive hematopoietic malignancies and has been recognized as a heterogeneous disease due to a lack of unifying characteristics. It is driven by different genome aberrations, gene expression changes, and epigenomic dysregulations.
openaire   +1 more source

Challenges in community-based recruitment of Alzheimer's disease cases: Experience of the monitoring drug efficacy through multi-omics research initiative in Alzheimer's disease (MEMORI-AD) study

Journal of Alzheimer's Disease Reports
Background The Monitoring drug Efficacy through Multi-Omics Research Initiative in Alzheimer's Disease (MEMORI-AD) study aims to characterize drug response to donepezil and memantine in a Filipino cohort with late-onset Alzheimer's disease (AD).
Fresthel Monica M Climacosa, Eric David B Ornos, Erwin Rommel S Diwa, Mary Gale R Guantia, Almeera P Qureshi, Nicole Clarence Louise L Gapaz, Aira B Dacasin, Joannes Luke B Asis, Ajina C Carampel, Angelica M Dela Cruz, Francis James A Gordovez, John Carlo B Reyes, Ian Kim B Tabios, Rafael Vincent M Manalo, Joana Marie C Cruz, Veeda Michelle M Anlacan   +15 more
doaj   +1 more source

Forensic Features and Genetic Structure Analyses of the Beijing Han Nationality Disclosed by a Self-Developed Panel Containing a Series of Ancestry Informative Deletion/Insertion Polymorphism Loci

Frontiers in Ecology and Evolution, 2022
The utilization of the ancestry informative markers to disclose the ancestral composition of a certain population and explore the genetic affinities between diverse populations is beneficial to inferring the biogeographic ancestry of unknown individuals ...
Hui Xu, Yating Fang, Ming Zhao, Qiong Lan, Shuyan Mei, Liu Liu, Xiaole Bai, Bofeng Zhu, Bofeng Zhu   +8 more
doaj   +1 more source

Assessment of Berberine as a Multi-target Antimicrobial: A Multi-omics Study for Drug Discovery and Repositioning

, 2014
Postgenomics drug development is undergoing major transformation in the age of multi-omics studies and drug repositioning. Rather than applications solely in personalized medicine, omics science thus additionally offers a better understanding of a ...
SAYAR, NİHAT ALPAGU, SARIYAR AKBULUT, BERNA   +1 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Goose multi-omics database: A comprehensive multi-omics database for goose genomics

Poultry Science
Multi-omics has helped elucidate the gene expression patterns and genomic variations closely associated with economically significant traits in geese. Despite the substantial genomic data generated through extensive goose studies, a unified platform for integrating these datasets is lacking.
Mingjiang Huang, Jiahe Sun, Jian Wang, Xiaoli Ye, Zhuping Chen, Xianzhi Zhao, Keshan Zhang, Lin Ma, Jiajia Xue, Yi Luo, Xianwen Wu, Haiwei Wang, Chao Wang, Zuohua Liu, Youhui Xie, Ying Chen, Qigui Wang, Yi Wang, Guangliang Gao   +18 more
openaire   +3 more sources

HPV specificity and multiple infections and association with cervical cytology in Chongqing, China: a cross-sectional study

BMC Infectious Diseases
Background It is important to assess the relationship between specific HPV genotype or multiple infection and cervical cytology. The protection provided by the HPV vaccine is type-specific, and the epidemiology feature of coinfections needs to be ...
Qinli Luo, Haiyan Zhang, Xianghua Zeng, Na Han, Zhen Ma, Hanyi Luo   +5 more
doaj   +1 more source