Results 31 to 40 of about 3,539,790 (303)
Metabolomics and the Multi-Omics View of Cancer [PDF]
Metabolites, 2022 Cancer is widely regarded to be a genetic disease. Indeed, over the past five decades, the genomic perspective on cancer has come to almost completely dominate the field. However, this genome-only view is incomplete and tends to portray cancer as a disease that is highly heritable, driven by hundreds of complex genetic interactions and, consequently ...
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Multi-Omics Approaches in Immunological Research [PDF]
Frontiers in Immunology, 2021 The immune system plays a vital role in health and disease, and is regulated through a complex interactive network of many different immune cells and mediators. To understand the complexity of the immune system, we propose to apply a multi-omics approach in immunological research.
Xiaojing Chu +13 more
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MODIMO: Workshop on Multi-Omics Data Integration for Modelling Biological Systems
, 2021 Multi-omics analysis aims at extracting previously uncovered biological knowledge by integrating information across multiple single-omic sources. Past approaches have focused on the simultaneous analysis of a small number of omic data sets.
Vincenzo Bonnici +5 more
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Nature Microbiology, 2016 Multi-omic techniques are often seen as the future of microbiome studies. We argue that recent strategies for simplifying complex omic-derived data will need to be combined with improved cultivation techniques to pave the way towards a more targeted approach for understanding microbial communities.
Vilanova, Cristina, Porcar, Manuel
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Learning from multi-omics data of cancer [PDF]
, 2022 Analysing multiple types of omics data is a keystone methodology in biomedical research nowadays. With the significant advances of high-throughput experimental technologies, an enormous amount of omics data with extremely high dimensionality are ...
Zhang, Xiaoyu
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Experimental and Molecular Medicine, 2023 Although the normal physiological level of oxidative stress is beneficial for maintaining bone homeostasis, imbalance between reactive oxygen species (ROS) production and antioxidant defense can cause various bone diseases.
Heein Yoon +9 more
doaj +1 more source
New Advances， Challenges and Opportunities in Forensic Applications of Microbiomics
Fayixue Zazhi, 2022 The succession of microbiota is closely associated with several essential factors, including race, sex, health condition, lifestyle, postmortem interval, etc., and it has great potential application value in forensic medicine.
LEI Fan-zhang +4 more
doaj +1 more source
Nanopore-based massively parallel sensing for peptide profiling and protein identification
Nature CommunicationsNanopore-based single-molecule sensing holds immense promise for revolutionizing proteomics, however, its practical application remains constrained by low throughput, suboptimal library preparation, and limited analytical power for complex, stochastic ...
Ji Wang +28 more
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The Advent of Omics Sciences in Clinical Trials of Motor Neuron Diseases
, 2022 The “omics revolution” has totally changed the scientific research approach and is contributing to the development of personalized therapies. In motor neuron diseases (MNDs), a set of complex, multifactorial, late-onset and chronic neurodegenerative ...
Cavallaro, Sebastiano +5 more
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FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source