Results 21 to 30 of about 53,428 (254)

Editorial: Multi-omic data integration [PDF]

Frontiers in Cell and Developmental Biology, 2015
As researchers involved in molecular biology, we are witnessing tremendous paradigm changes in a time frame that becomes shorter and shorter. The epoch-making notion, originally put forward by the central dogma of biology (Crick, 1970), that there is a unidirectional process and a privileged level (genetic) of causality at which biological functions ...
Christine eNardini, Christine eNardini, Jennifer eDent, Paolo eTieri   +3 more
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Applications of multi‐omics analysis in human diseases

MedComm, 2023
Multi‐omics usually refers to the crossover application of multiple high‐throughput screening technologies represented by genomics, transcriptomics, single‐cell transcriptomics, proteomics and metabolomics, spatial transcriptomics, and so on, which play ...
Chongyang Chen, Jing Wang, Donghui Pan, Xinyu Wang, Yuping Xu, Junjie Yan, Lizhen Wang, Xifei Yang, Min Yang, Gong‐Ping Liu   +9 more
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Applications of Multi-Omics Technologies for Crop Improvement

Frontiers in Plant Science, 2021
Multiple “omics” approaches have emerged as successful technologies for plant systems over the last few decades. Advances in next-generation sequencing (NGS) have paved a way for a new generation of different omics, such as genomics, transcriptomics, and
Yaodong Yang, Mumtaz Ali Saand, Mumtaz Ali Saand, Liyun Huang, Walid Badawy Abdelaal, Jun Zhang, Yi Wu, Jing Li, Muzafar Hussain Sirohi, Fuyou Wang   +9 more
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scBridge embraces cell heterogeneity in single-cell RNA-seq and ATAC-seq data integration

Nature Communications, 2023
Single-cell multi-omics data integration aims to reduce the omics difference while keeping the cell type difference. However, it is daunting to model and distinguish the two differences due to cell heterogeneity.
Yunfan Li, Dan Zhang, Mouxing Yang, Dezhong Peng, Jun Yu, Yu Liu, Jiancheng Lv, Lu Chen, Xi Peng   +8 more
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Network approaches for omics studies of neurodegenerative diseases

Frontiers in Genetics, 2022
The recent methodological advances in multi-omics approaches, including genomic, transcriptomic, metabolomic, lipidomic, and proteomic, have revolutionized the research field by generating “big data” which greatly enhanced our understanding of the ...
Na Zhao, Zachary Quicksall, Yan W. Asmann, Yingxue Ren   +3 more
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Integrated Multi-Omics Landscape of Liver Metastases

Gastroenterology, 2023
Lack of thorough knowledge about the complicated immune microenvironment (IM) within a variety of liver metastases (LMs) leads to inappropriate treatment and unsatisfactory prognosis. We aimed to characterize IM subtypes and investigate potential mechanisms in LMs.Mass cytometry was applied to characterize immune landscape of a primary liver cancers ...
Shuai Yang, Ling Qian, Zhixuan Li, Ye Li, Jian Bai, Bo Zheng, Kun Chen, Xinyao Qiu, Guoxiang Cai, Shan Wang, Haiyan Huang, Jianmin Wu, Yanjing Zhu, Qianwen Zhangyang, Lanyun Feng, Tong Wu, Rui Wu, Airong Yang, Kaiting Wang, Ruiru Wang, Yani Zhang, Yan Zhao, Wenwen Wang, Jinxia Bao, Siyun Shen, Ji Hu, Xuan Wu, Tao Zhou, Zhiqiang Meng, Weiwei Liu, Hongyang Wang, Peng Wang, Lei Chen   +32 more
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MSPL: Multimodal Self-Paced Learning for Multi-Omics Feature Selection and Data Integration

IEEE Access, 2019
Rapid advances in high-throughput sequencing technology have led to the generation of a large number of multi-omics biological datasets. Integrating data from different omics provides an unprecedented opportunity to gain insight into disease mechanisms ...
Zi-Yi Yang, Liang-Yong Xia, Hui Zhang, Yong Liang   +3 more
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A Customizable Analysis Flow in Integrative Multi-Omics [PDF]

Biomolecules, 2020
The number of researchers using multi-omics is growing. Though still expensive, every year it is cheaper to perform multi-omic studies, often exponentially so. In addition to its increasing accessibility, multi-omics reveals a view of systems biology to an unprecedented depth.
Samuel M. Lancaster, Akshay Sanghi, Si Wu, Michael P. Snyder   +3 more
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Integrative Multi-omics Analysis of Childhood Aggressive Behavior [PDF]

Behavior Genetics, 2021
Abstract This study introduces and illustrates the potential of an integrated multi-omics approach in investigating the underlying biology of complex traits such as childhood aggressive behavior. In 645 twins (cases = 42%), we trained single- and integrative multi-omics models to identify biomarkers for ...
Hagenbeek, Fiona, van Dongen, Jenny, Pool, René, Roetman, Peter, Harms, Amy, Hottenga, Jouke Jan, Kluft, Cornelis, Colins, Olivier, van Beijsterveldt, Catharina, Fanos, Vassilios, Ehli, Erik, Hankemeier, Thomas, Vermeiren, Robert, Bartels, Meike, Déjean, Sébastien, Boomsma, Dorret   +15 more
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Integrating multi-omics data for crop improvement

Journal of Plant Physiology, 2021
Our agricultural systems are now in urgent need to secure food for a growing world population. To meet this challenge, we need a better characterization of plant genetic and phenotypic diversity. The combination of genomics, transcriptomics and metabolomics enables a deeper understanding of the mechanisms underlying the complex architecture of many ...
Scossa, Federico, Alseekh, Saleh, Fernie, Alisdair R.   +2 more
openaire   +3 more sources