Results 31 to 40 of about 55,469 (246)

Three-dimensional multi-mechanism bounding surface model for sands

Yantu gongcheng xuebao, 2017
Within the multi-mechanism framework, a novel constitutive model for sands is proposed based on the critical state and bounding surface plasticity theories. The model assumes that the macroscopic deformation behavior of sands can be obtained by summation
FANG Huo-lang 1, 2, SHEN Yang 1, ZHENG Hao 1, ZENG Ze-bin 3
doaj   +1 more source

Deep phenotyping of coarse root architecture in R. pseudoacacia reveals that tree root system plasticity is confined within its architectural model. [PDF]

PLoS ONE, 2013
This study aims at assessing the influence of slope angle and multi-directional flexing and their interaction on the root architecture of Robinia pseudoacacia seedlings, with a particular focus on architectural model and trait plasticity.
Frédéric Danjon, Hayfa Khuder, Alexia Stokes   +2 more
doaj   +1 more source

The modified cyclic multi-surface plastic model of sandy soil based on damping ratio

IOP Conference Series: Earth and Environmental Science, 2020
Abstract Traditional multi-surface plastic model always overestimates the accumulated plastic strain when it is applied into sandy soil under cyclic loading. Considering this overestimation can be reflected through equivalent damping ratio of the hysteretic loop and the damping ratio can also include the real anisotropic plastic ...
Yan Zhang, Shulin Sun, You Qin
openaire   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Novel plastic loop topologies in pure Mg and orientation-dependent fracture of β-Mg₁₇Al₁₂ precipitates under shallow scratching

Journal of Magnesium and Alloys
Understanding how microstructural heterogeneity governs nanoscale deformation under surface-dominated loading is a fundamental challenge in lightweight alloy design.
Saurav Goel, Gaurav Goel, Rajab Alsayegh, Jaya Verma   +3 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Investigating Plastic Anisotropy of Single and Two-Phase (α₂-Ti₃Al + γ-TiAl) PST-TiAl Through Computational Yield Surface Analysis

Metals
The anisotropic mechanical behaviour of multi-phase TiAl alloys is intrinsically governed by the anisotropic crystal properties and morphology of their constituent phases, which control the initiation of local plasticity.
Mohammad Rizviul Kabir, Muhammed Bahadir Murat   +1 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source