Results 211 to 220 of about 181,836 (261)
Some of the next articles are maybe not open access.
Breast Cancer Research and Treatment, 1984
Mutations resulting in a complex phenotype of cross-resistance and collateral-sensitivity are frequently observed in mammalian cell lines. A cell surface 170 000 dalton glycoprotein (P-glycoprotein) has been identified to be intimately associated with this multidrug resistance phenotype.
V, Ling, J, Gerlach, N, Kartner
openaire +2 more sources
Mutations resulting in a complex phenotype of cross-resistance and collateral-sensitivity are frequently observed in mammalian cell lines. A cell surface 170 000 dalton glycoprotein (P-glycoprotein) has been identified to be intimately associated with this multidrug resistance phenotype.
V, Ling, J, Gerlach, N, Kartner
openaire +2 more sources
Anti-Cancer Drugs, 1995
Since we found verapamil as a multidrug resistance (MDR) reversing agent in 1981, many MDR reversing compounds have been reported. This type of drug must have strong effects with little side effects. We recently found MS-209 and PSC-833 as reversing agents.
T, Tsuruo, A, Tomida
openaire +2 more sources
Since we found verapamil as a multidrug resistance (MDR) reversing agent in 1981, many MDR reversing compounds have been reported. This type of drug must have strong effects with little side effects. We recently found MS-209 and PSC-833 as reversing agents.
T, Tsuruo, A, Tomida
openaire +2 more sources
Doxorubicin and multidrug resistance
Current Opinion in Oncology, 1993The circumvention of P-glycoprotein function by pharmacologic agents is a major focus of clinical trials aimed at increasing the cytotoxicity of multidrug resistance-associated drugs, including doxorubicin. The success of this approach will likely depend on the clinical significance of P-glycoprotein expression, which has not yet been elucidated for ...
G D, Kruh, L J, Goldstein
openaire +2 more sources
Der Urologe A, 1996
The past decade has seen the successful application of genetic techniques in the dissection of the most important phenotypes of cancer cells. In the case of drug resistance mechanisms, the elucidation of the genes involved in resistance to anticancer agents has led to new and unexpected information about tumor physiology and may well open therapeutic ...
openaire +2 more sources
The past decade has seen the successful application of genetic techniques in the dissection of the most important phenotypes of cancer cells. In the case of drug resistance mechanisms, the elucidation of the genes involved in resistance to anticancer agents has led to new and unexpected information about tumor physiology and may well open therapeutic ...
openaire +2 more sources
Multidrug resistance in leukemia
1993Over the last 20 years, advances in chemotherapy have improved the outcome in a number of cancers, most notably in the acute leukemias, lymphomas, testicular carcinoma, and several pediatric malignancies. Despite the advances in the treatment of the acute leukemias with very high remission rates to initial chemotherapy and significant cure rates, many ...
D, Rischin, V, Ling
openaire +2 more sources
Multidrug Resistance in Plague
New England Journal of Medicine, 1997Untreated, human plague is often fulminant and fatal,1 which reinforces its historical reputation as a devastating disease. Plague is a zoonosis of rodents and their fleas caused by Yersinia pestis, a member of the family Enterobacteriaceae. People are usually infected by bites from fleas found on rodents, occasionally by direct contact with infectious
D T, Dennis, J M, Hughes
openaire +2 more sources
Multidrug resistance in leukemia
Current Opinion in Hematology, 1998Resistance of tumors to chemotherapeutic agents is an important factor that limits the successful treatment of a wide range of malignancies. The multidrug resistant (MDR) phenotype is well recognized in clinical samples, and it has been extensively studied, particularly in acute myeloid leukemia.
openaire +2 more sources
The reversal of multidrug resistance
1995The failure of chemotherapy to achieve complete and durable responses has been attributed in large part to the phenomenon of drug resistance. In the laboratory, tumor cells can be selected for resistance to a particular cytotoxin by repeated exposure to that drug.
G A, Fisher, B L, Lum, B I, Sikic
openaire +2 more sources
Microbial multidrug resistance
International Journal of Antimicrobial Agents, 1997Multiresistance plasmids and transposons, the integrons, the co-amplification of several resistance genes or finally the accumulation of independent mutations can lead to microorganisms resistant to multiple drugs. On the other hand multidrug resistance is due to an efflux pump conferring resistance to unrelated drugs.
M, Ouellette, C, Kündig
openaire +2 more sources