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Multidrug-resistant tuberculosis
Clinica Chimica ActaOne of predominant contributors to global mortality is tuberculosis (TB), an infection caused by Mycobacterium tuberculosis (MTB). Inappropriate and ineffectual treatment can lead to the development of drug-resistant TB. One of the most common forms of drug-resistant TB is multidrug-resistant tuberculosis (MDR-TB), caused by mutations in the rpoB and ...
Dika Apriliana, Wulandari +4 more
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Multidrug Resistance in Leukaemia
Leukemia & Lymphoma, 1990The treatment of many haematological malignancies is complicated by the development of resistance to cytotoxic agents. Cells which acquire the multidrug resistant (MDR) phenotype lose sensitivity to a spectrum of structurally unrelated chemotherapeutic drugs.
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Multidrug resistance and mutagenesis
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1993Multidrug resistance, the phenomenon whereby the development of resistance to one drug is sometimes accompanied by the simultaneous development of resistance to a variety of other, often structurally unrelated, drugs, is frequently associated with the presence of an energy-dependent membrane-transport system which reduces the concentration of a drug or
L R, Ferguson, B C, Baguley
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Multidrug Resistance in Anaerobes
Future Microbiology, 2019Multidrug resistance (MDR) in anaerobes is not a well-known topic. Bacteroides fragilis group isolates have numerous resistance determinants such as multidrug efflux pumps, cfiA and nimB genes and activating insertion sequences, and some isolates exhibited extensive drug-resistant patterns. MDR rates in B. fragilis group were from 1.5 to >18% and up to
Lyudmila Boyanova +2 more
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Multidrug Resistance in Cancer
Scientific American, 1989Chemotherapy often fails because a tumor develops resistance to an array of different drugs. A single glycoprotein turns out to be responsible: it proliferates in some cells and pumps out the drugs. Now that the protein pump has been identified it may be possible to interfere with its action or to make it the target for drugs that destroy the cancer ...
N, Kartner, V, Ling
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Inhibitors of multidrug resistance
Current Opinion in Oncology, 1997P-glycoprotein expression on tumor cells is a frequent cause of pleiotropic drug resistance in cell lines and tumor specimens. Besides the multidrug resistance gene (MDR1), other mechanisms of increased drug extrusion have been described, such as the MDR-related protein and the lung resistance protein.
Sonneveld, Pieter, Wiemer, Erik
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Multidrug-Resistance Transporters
2002P-glycoprotein was initially isolated due to its role in multidrug resistance to cancer chemotherapeutics. Recent work, however, makes it increasingly apparent that this transporter is also involved in the pharmacokinetics of many drugs. P-gp is strategically expressed in the luminal epithelial cells of organs often associated with drug absorption and ...
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Multidrug resistance in leukaemia
Baillière's Clinical Haematology, 1992Multidrug resistance hampers successful chemotherapy in many haematological neoplasms and is mediated by several cellular proteins. In some cases, the genes encoding these proteins have been shown to confer resistance on transfer to drug-sensitive cell lines. This is true for the efflux pump product of the MDR1 gene, P-170. Upregulation of enzymes such
P, Baines, P, Cumber, R A, Padua
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Reversal of Multidrug Resistance
Journal of Hematotherapy, 1994S E, Bates +7 more
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MULTIDRUG RESISTANCE IN LEUKAEMIA
British Journal of Haematology, 1997S L, McKenna, R A, Padua
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