Results 91 to 100 of about 235,517 (308)

Pharmacological Inhibition of FKBP51 Mitigates Early Life Adversity‐Induced Social Deficits in Male Mice

Advanced Science, EarlyView.
Early life adversity triggers persistent social subordination and brain‐wide molecular dysregulation. Pharmacological inhibition of the stress‐mediator FKBP51 during the adversity period prevents these long‐term deficits and restores normative social hierarchy.
Joeri Bordes, Xiuqi Ji, Serena Gasperoni, Choham Sudre‐Chinsky, Amirali Kalbasi, Daniela Harbich, Cornelia Flachskamm, Paula Fontanet, Sowmya Narayan, Manfred Uhr, Christian Namendorf, Camilla Bellone, Alon Chen, Felix Hausch, Juan Pablo Lopez, Mathias V. Schmidt   +15 more
wiley   +1 more source

Randomised trial of chloroquine/sulphadoxine-pyrimethamine in Gambian children with malaria: impact against multidrug-resistant P. falciparum. [PDF]

, 2006
OBJECTIVES: In the Gambia, the combination of chloroquine (CQ) and sulphadoxine-pyrimethamine (SP) has replaced CQ monotherapy for treatment of malaria caused by Plasmodium falciparum. We measured the efficacy of the combination CQ/SP, and the prevalence
Targett Geoffrey A. T, Sutherland Colin J, Samuel Dunyo, Jawara, Musa, Coleman, Rosalind, Alexander Neal, Mesa, Eduardo, Sutherland, Colin J, Hallett, Rachel, Rachel Hallett, Ord Rosalynn, Coleman Rosalind, Musa Jawara, Geoffrey A. T Targett, Pinder Margaret, Jawara Musa, Ord, Rosalynn, Walraven, Gijs, Sowe, Maimuna, Targett, Geoffrey AT, Eduardo Mesa, Dunyo, Samuel, Neal Alexander, Colin J Sutherland, Rosalind Coleman, Gijs Walraven, Sowe Maimuna, Walraven Gijs, Mesa Eduardo, Alexander, Neal, Margaret Pinder, Dunyo Samuel, Rosalynn Ord, Maimuna Sowe, Pinder, Margaret, Hallett Rachel   +35 more
core   +1 more source

Establishment of a Multidrug Resistance Cell Line A549/cDDP of Human Lung Adenocarcinoma and Expression Analysis of Multidrug Resistance-Associated Genes

Chinese Journal of Lung Cancer, 2009
Background and objective It has been proven that chemotherapy failure caused by multidrug resistance in lung tumor cells is the main cause for the patient's survival rate.
Yongcheng PAN, Weigang ZHAO, Jianjun WANG, Quan LIU, Guanghai YANG, Jinsong LI   +5 more
doaj  

Multi‐Targeting Carnosic Acid Kills Drug‐Resistant Helicobacter pylori With Narrow‐Spectrum Activity

Advanced Science, EarlyView.
Carnosic acid selectively eradicates drug‐resistant Helicobacter pylori through a multi‐targeted mechanism involving urease inhibition, membrane disruption, and biofilm eradication. It exhibits no detectable resistance, potent in vivo efficacy, and minimal impact on gut microbiota, positioning it as a promising narrow‐spectrum lead compound against ...
Yuefan Bai, Hongming Huang, Xudong Hang, Shanwei Hu, Qian Tong, Jingchen Xu, Jia Jia, Hongkai Bi   +7 more
wiley   +1 more source

Development of taxane resistance in a panel of human lung cancer cell lines [PDF]

, 2008
Using a selection process designed to reflect clinically relevant conditions, a panel of taxane-selected variants were developed to study further the mechanisms of resistance in lung cancer.
Keenan, Joanne, Breen, Laura, Murphy, Lisa, Clynes, Martin   +3 more
core   +1 more source

Suppressed Protein Translation Caused by MSP‐8 Deficiency Determines Fungal Multidrug Resistance with Fitness Cost

Advanced Science
Antifungal resistance, particularly the rise of multidrug‐resistance strains, poses a significant public health threat. In this study, the study identifies a novel multidrug‐resistance gene, msp‐8, encoding a helicase, through experimental evolution with
Mi Zhou, Pengju Yu, Chengcheng Hu, Wenxia Fang, Cheng Jin, Shaojie Li, Xianyun Sun   +6 more
doaj   +1 more source

High prevalence of antimicrobial resistance genes in multidrug-resistant-ESBLs-producing Klebsiella pneumoniae post-COVID-19 pandemic

Iranian Journal of Microbiology
Background and Objectives: Klebsiella pneumoniae is a common pathogen associated with healthcare-related infections. It is particularly notable for its ability to develop resistance to multiple antibiotics, making treatment challenging. During the COVID-
Golnar Rahimzadeh, Shaghayegh Rezai, Ghazal Abbasi, Saman Soleimanpour, Reza Valadan, Laleh Vahedi, Somayeh Sheidaei, Faezeh Sadat Movahedi, Raha Rezai, Mohammad Sadegh Rezai   +9 more
doaj   +1 more source

Characterization of Posttranslationally Modified Multidrug Efflux Pumps Reveals an Unexpected Link between Glycosylation and Antimicrobial Resistance

mBio, 2020
The substantial rise in multidrug-resistant bacterial infections is a current global imperative. Cumulative efforts to characterize antimicrobial resistance in bacteria has demonstrated the spread of six families of multidrug efflux pumps, of which ...
Sherif Abouelhadid, John Raynes, Tam Bui, Jon Cuccui, Brendan W. Wren   +4 more
doaj   +1 more source

Conformational Snapshots of CydDC in a Native Lipid Bilayer Coupling Heme Transport to Antibiotic Resistance

Advanced Science, EarlyView.
Phylogenetic and biochemical analyses of the heme transporter CydDC reveal its functional conservation throughout bacterial evolution and demonstrate its unique asymmetric allosteric mechanism. Furthermore, impairment of CydDC function directly affects bacterial antibiotic resistance and likely compromises antibiotic efficacy through drug efflux.
Lili Yang, Changbin Zhang, Mengyuan Lyu, Yongbo Luo, Jierou Zhang, Yujiao Chen, Lintao Luo, Wen Qiao, Xiangyangpeng Li, Yu Zhou, Zhongling Wei, Yuling Xiao, Qian Niu, Juan Zhou, Guanglin He, Binwu Ying, Zhaoming Su, Hao Chen, Xiaodi Tang, Haohao Dong   +19 more
wiley   +1 more source

Role of Multidrug Resistance Associated Proteins in Drug Development [PDF]

, 2012
The Multidrug Resistance Associated Proteins ((MRP1, MRP2, MRP3, MRP4, MRP5, MRP6, MRP7, MRP8 and MRP9) belong to the ATP-binding cassette superfamily (ABCC family) of transporters expressed differentially in the liver, kidney, intestine and blood-brain ...
Liu, Jun-Ping, Zhou, Shu-Feng, Wei, Ming Qian, Duan, Wei   +3 more
core