Results 71 to 80 of about 349,410 (289)

Draft Genome Sequence of Multidrug-Resistant Abortive Campylobacter jejuni from Northern California. [PDF]

, 2017
Campylobacter jejuni is an enteric bacterium that can cause abortion in livestock. This is the release of a multidrug-resistant Campylobacter jejuni genome from an isolate that caused an abortion in a cow in northern California.
Clothier, Kristin A, Huang, Bihua C, Kong, Nguyet, Weimer, Bart C, Weis, Allison M   +4 more
core   +2 more sources

Dual‐Peptide Nanoplatform: Mesoporous Silica Nanoparticles Functionalized With a Cell‐Penetrating Peptide and Loaded With Rationally Designed Antimicrobial Peptides for Tuberculosis Therapy

Advanced Healthcare Materials, EarlyView.
Machine learning–guided engineering of a plectasin‐derived peptide yields DC05, a potent antimycobacterial candidate. Encapsulation into tuftsin‐functionalized mesoporous silica nanoparticles enhances intracellular delivery, stability, and activity against Mycobacterium tuberculosis while maintaining low cytotoxicity and minimal hemolysis. The combined
Christian S. Carnero Canales, Cesar Augusto Roque‐Borda, Ana Carolina Cerqueira Negri, Oswaldo Ramirez Delgado, Letícia Oliveira Catarin Nunes, Flávia Aparecida Resende, Hernane Barud, Norival Alves Santos‐Filho, Saulo Santesso Garrido, Karen Cristina Oliveira, Alexandra Ivo de Medeiros, Rafael Miguel Sábio, Fernando Rogério Pavan   +12 more
wiley   +1 more source

Exosomal microRNA-32-5p induces multidrug resistance in hepatocellular carcinoma via the PI3K/Akt pathway

Journal of Experimental & Clinical Cancer Research, 2018
Background Multidrug resistance is the main obstacle for hepatocellular carcinoma (HCC) treatment. miR-32-5p is involved in HCC progression but its function in multidrug resistance is still unclear.
Xiao Fu, Mengjie Liu, Shengyang Qu, Jiequn Ma, Yamin Zhang, Tingting Shi, Hongqing Wen, Yujuan Yang, Shuhong Wang, Jing Wang, Kejun Nan, Yu Yao, Tao Tian   +12 more
doaj   +1 more source

Sentinel Case of Candida auris in the Western United States Following Prolonged Occult Colonization in a Returned Traveler from India. [PDF]

, 2019
Candida auris is an emerging multidrug-resistant yeast with high mortality. We report the sentinel C. auris case on the United States West Coast in a patient who relocated from India.
Crawford, Emily D, Derisi, Joseph L, Doernberg, Sarah B, Dynerman, David, Langelier, Charles, Li, Lucy M, Lyden, Amy, Miller, Steve, Nichols, Amy, Ramirez-Avila, Lynn, Serpa, Paula Hayakawa, Tato, Cristina M, Woodworth, Michael H   +12 more
core   +1 more source

Paracrine Factor Local Gradient‐Generating System for Engineering Perfusable Vascularized Hepatocyte Tissues with Perfusion‐Induced Proliferation

Advanced Healthcare Materials, EarlyView.
A paracrine factor local gradient (PFLG)‐generating system enables microvessel penetration across 3D hepatocyte tissues. The resulting vascularized constructs recapitulate hepatic sinusoidal hepatocyte—endothelial contact architecture and enhance hepatic functions in vitro.
Yen‐Hsiang Huang, Tadahiro Yamashita, Ryo Sudo   +2 more
wiley   +1 more source

Resistance to paclitaxel induces glycophenotype changes and mesenchymal-to-epithelial transition activation in the human prostate cancer cell line PC-3

Tumor Biology, 2020
The development of the multidrug resistance phenotype is one of the major challenges faced in the treatment of cancer. The multidrug resistance phenotype is characterized by cross-resistance to drugs with different chemical structures and mechanisms of ...
Leonardo Marques da Fonseca, Danilo Macedo Calvalhan, Jose Osvaldo Previato, Lucia Mendonça Previato, Leonardo Freire-de-Lima   +4 more
doaj   +1 more source

Novel 5-oxo-hexahydroquinoline derivatives: design, synthesis, in vitro P-glycoprotein-mediated multidrug resistance reversal profile and molecular dynamics simulation study [PDF]

, 2017
Overexpression of the efflux pump P-glycoprotein (P-gp) is one of the important mechanisms of multidrug resistance (MDR) in many tumor cells. In this study, 26 novel 5-oxo-hexahydroquinoline derivatives containing different nitrophenyl moieties at C-4 ...
Edraki, N., Firuzi, O., Khoshneviszadeh, M., Miri, R., Ranjbar, S., Saso, L., Shahraki, O., Zargari, F.   +7 more
core   +1 more source

Airborne 1O2 Delivery via a Superhydrophobic Dressing as a Pathway to Next‐Generation Wound Therapies, an in Vivo Murine Burn Model Study

Advanced Healthcare Materials, EarlyView.
Schematic illustration of the SH bandage placed on an infected burn wound and its role in wound healing. A superhydrophobic PDMS membrane coated with the PS verteporfin is placed over the wound area and illuminated with a red laser at 690 nm, generating airborne 1O2 above the tissue.
Fernanda Viana Cabral, QianFeng Xu, Natalie Eidenschink, Pareesha Haresh, Alessandra Nara de Souza Rastelli, Jeremy Goverman, Alexander Greer, Alan M. Lyons, Tayyaba Hasan   +8 more
wiley   +1 more source

Critical roles of Hedgehog signaling pathway in regulating the multidrug resistance of ovarian cancer

Journal of Ovarian Research
Ovarian cancer (OC) is a life-threatening disease with high morbidity and mortality rates among women. Treatment inevitably requires the use of multiple drugs, including platinum-based agents, taxanes, and targeted therapies, across all stages and ...
Ruixue Bi, Xiangyu Dong, Bingjie Cui, Hongliang Dong, Cuilan Liu, Weiwei Chen, Jianwei Liu, Zhiqiang Liu, Jing Du, Fei Wang   +9 more
doaj   +1 more source

Mechanisms of cross resistance between cisplatin and bleomycin in saccharomyces cerevisiae [PDF]

, 2019
Tumor cells can simultaneously acquire resistance against a diverse group of drugs. This phenomenon is called pleotropic resistance or multidrug resistance.
Burgos-Molina, Antonio Manuel, Gil-Carmona, Luisa, Ruiz-Gomez, Miguel Jose   +2 more
core