Results 51 to 60 of about 235,517 (308)

Role in routing to the plasma membrane of the L 0 domain of the multidrug resistance protein MRP1 [PDF]

, 2004
Die mehrfache Chemotherapieresistenz (Multidrug Resistance) beruht auf vermehrtem Transport von Xenobiotika aus der Zelle, was zu einer dramatischen Verringerung der intrazellulären Konzentration von chemotherapeutischen Substanzen führt.
Calenda, Giulia
core  

Complementary supramolecular drug associates in perfecting the multidrug therapy against multidrug resistant bacteria

Frontiers in Immunology
The inappropriate and inconsistent use of antibiotics in combating multidrug-resistant bacteria exacerbates their drug resistance through a few distinct pathways.
Pathik Sahoo, Pathik Sahoo
doaj   +1 more source

Emerging crisis of multidrug-resistant enterococci from a rural tertiary care hospital of North India

Indian Journal of Health Sciences and Biomedical Research KLEU, 2021
INTRODUCTION: Enterococci are emerging as a major pathogen causing a variety of hospital-acquired nosocomial infections and community-acquired infections contributing significantly to patient's morbidity and mortality.
Jyoti Sangwan, Kirti Lohan, Pratibha Mane, Mukesh Kumar   +3 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Nucleotide-Binding Sites of the Heterodimeric LmrCD ABC-Multidrug Transporter of Lactococcus lactis Are Asymmetric [PDF]

, 2006
LmrCD is a lactococcal, heterodimeric multidrug transporter, which belongs to the ABC superfamily. It consists of two half-transporters, LmrC and LmrD, that are necessary and sufficient for drug extrusion and ATP hydrolysis.
Konings, Wil N., Lubelski, Jacek, Konings, Wil N.,, Merkerk, Ronald van, Lubelski, Jacek,, Merkerk, Ronald van,, Driessen, Arnold J.M.,, Driessen, Arnold J.M.   +7 more
core   +1 more source

Identification and characterisation of a novel multidrug-resistant streptococcus, Streptococcus toyakuensis sp. nov., from a blood sample

Journal of Global Antimicrobial Resistance, 2022
: Objectives: In 2018, we isolated multidrug-resistant α-haemolytic streptococci TP1632 from the blood of a 34-year-old patient with bacteraemia. This study aimed to characterise α-haemolytic streptococci TP1632 and elucidate its multidrug resistance ...
Takeaki Wajima, Atsuya Hagimoto, Emi Tanaka, Yoshiaki Kawamura, Hidemasa Nakaminami   +4 more
doaj   +1 more source

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source

Mechanisms of multidrug resistance in bladder cancer: the role of the nuclear membrane [PDF]

, 2007
Multidrug resistance (MDR) describes the phenomenon whereby cancer cellsexposed to a single cytotoxic drug develop cross resistance to numerous otherstructurally unrelated chemotherapeutics.
Featherstone, Jonathan Mark
core  

Lipid bilayer composition influences small multidrug transporters [PDF]

, 2008
Background: Membrane proteins are influenced by their surrounding lipids. We investigate the effect of bilayer composition on the membrane transport activity of two members of the small multidrug resistance family; the Escherichia coli transporter, EmrE
Charalambous, K, Curnow, Paul, Curnow, P., Curnow, P, Miller, D, Charalambous, Kalypso, Booth, Paula J, Miller, D., Booth, P.J., Miller, David, Booth, PJ   +10 more
core   +1 more source

Multidrug resistant tuberculosis [PDF]

BMJ, 2015
#### The bottom line Tuberculosis remains a major cause of morbidity and mortality globally, with an estimated nine million people developing the disease and 1.5 million deaths in 2013; equating to 4100 deaths a day.1 Nevertheless, considerable gains have been made in international tuberculosis control; incidence rates are decreasing (albeit slowly ...
Millard, James, Ugarte-Gil, Cesar, Moore, David AJ   +2 more
openaire   +2 more sources