Results 61 to 70 of about 235,517 (308)

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Elucidation of the structure and molecular mechanism of the tripartite multidrug efflux pumps in the Gram-negative pathogens: Vibrio cholerae and Neisseria gonorrhoeae [PDF]

, 2006
In bacteria, multidrug efflux systems have been identified as significant determinants of resistance recently. These resistance pumps are widely distributed in bacterial species and many pathogenic bacteria posses them, which play an important role in ...
Du, Dijun
core  

Prevalence and transmission risk of colistin and multidrug resistance in long-distance coastal aquaculture [PDF]

, 2023
Due to the wide use of antibiotics, intensive aquaculture farms have been recognized as a significant reservoir of antibiotic resistomes. Although the prevalence of colistin resistance genes and multidrug-resistant bacteria (MDRB) has been documented ...
Zhao, Huijun, An, Taicheng, Wong, Po Keung, Cai, Yiwei, Li, Shaoting, Guo, Jianhua, Li, Guiying   +6 more
core   +1 more source

Experimental Evolution of Multidrug Resistance in Neurospora crassa under Antifungal Azole Stress

Journal of Fungi, 2022
Multidrug resistance, defined as the resistance to multiple drugs in different categories, has been an increasing serious problem. Limited antifungal drugs and the rapid emergence of antifungal resistance prompt a thorough understanding of how the ...
Mi Zhou, Chengcheng Hu, Yajing Yin, Jingji Wang, Shuting Ye, Yifa Yu, Xianyun Sun, Shaojie Li   +7 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Multidrug-resistant tuberculosis

The Brazilian Journal of Infectious Diseases, 2013
Despite the efforts made worldwide to reduce the number of cases of drug-susceptible tuberculosis, multidrug-resistant tuberculosis (MDR-TB) constitutes an important public health issue. Around 440,000 new cases of MDR-TB are estimated annually, although in 2008 only 7% of these (29,423 cases) were notified.
Lemos, Antônio Carlos Moreira, Matos, Eliana Dias   +1 more
openaire   +9 more sources

Multidrug resistance in cancer [PDF]

BMJ, 1994
Malignant neoplasms vary in their response to cytotoxic drugs: some are sensitive, others resistant. Understanding of the biochemical basis of this resistance might lead to the development of markers that would correlate with the clinical response to the drugs - or even lead to ways of overcoming the resistance.
D R, Ferry, D J, Kerr
openaire   +2 more sources

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Pharmacological modulation and manipulation of cancer drug resistance [PDF]

, 2010
The aim of this project was to investigate pharmacological methods of overcoming resistance in cancer. Novel compounds, targeted therapies and non-steroidal anti-inflammatory drugs (NSAIDs) were examined for their potential to modulate and manipulate ...
Devery, Aoife
core  

Antimicrobial and Efflux Pump Inhibitory Activity of Caffeoylquinic Acids from Artemisia absinthium against Gram-Positive Pathogenic Bacteria [PDF]

, 2010
Background: Traditional antibiotics are increasingly suffering from the emergence of multidrug resistance amongst pathogenic bacteria leading to a range of novel approaches to control microbial infections being investigated as potential alternative ...
Han Haley, Jacques Vervoort, Alexandre M. J. J. Bonvin, George P Tegos, Lewis Kim, Panagiotis L. Kastritis, Vervoort, J., NMR Spectroscopy, Michael R. Hamblin, Kastritis, P., Vervoort Jacques, Exarchou, Vassiliki, Vervoort, Jacques, Bonvin, A.M., Kastritis Panagiotis L., Hamblin, Michael, Tegos, George, Tegos, George P., Lewis, K., Kim Lewis, George P. Tegos, Bonvin, Alexandre M. J. J., Panagiotis L Kastritis, Bonvin Alexandre M. J. J., Sub NMR Spectroscopy, Han, H., Tegos, G.P., Alexandre M J J Bonvin, Fiamegos Yiannis C., Fiamegos, Y.C., Yiannis C Fiamegos, Kastritis, P.L., Hamblin, Michael R., Exarchou Vassiliki, Lewis, Kim, Exarchou, V., Han, Haley, Hamblin Michael R., Tegos George P., Michael R Hamblin, Fiamegos, Yiannis C., Haley Han, Yiannis C. Fiamegos, Kastritis, Panagiotis L., Vassiliki Exarchou, Bonvin, A.M.J.J., Hamblin, M.R., Vervoort, J.J.M.   +47 more
core   +1 more source