Results 111 to 120 of about 235,517 (308)
Advanced Science, EarlyView.This study unravels that bone fracture accelerates diabetic wound healing by releasing exosomal microRNA (miR‐130b‐3p). To mimic this bone‐skin crosstalk, we engineered a self‐assembling agomir‐130b‐3p nanocomplex. Delivered via a photocrosslinkable hydrogel, this bio‐inspired therapy provides sustained localized agomir release.
Tao Shen +14 more
wiley +1 more source
Increased Multidrug Resistance-Associated Protein Activity in Mononuclear Cells of Patients with Systemic Lupus Erythematosus [PDF]
, 2011 Multidrug resistance-associated proteins (MRPs, ATP binding cassette sub- family C). P-glycoprotein (P-gp) and ATP binding cassette (ABC) sub-family G member 2 (APCG2) are important drug efflux pumps emerging after long- term medications.
LU, MING-CHI;LAI, NING-SHENG;LI, KO-JEN;HSIEH, SONG-CHOU;WU, CHENG-HAN;YU, CHIA-LI +1 more
core
Advanced Science, EarlyView.Lipid nanostructured particles with increasing negative Gaussian curvature progress from vesicles to P‐cubosomes and D‐cubosomes. This curvature hierarchy enhances interaction with bacterial membranes, promotes membrane remodeling and leakage, and potentiates daptomycin activity against MRSA.
Xiangfeng Lai +10 more
wiley +1 more source
Investigation of the intrinsic mechanism of drug resistance in multiple myeloma [PDF]
, 2011 The focus of this thesis was to evaluate the mechanisms whereby myeloma cells develop intrinsic resistance with a focus on resistance in the context of bortezomib treatment.
Ooi, Melissa
core
Multidrug-resistance patterns of P. aeruginosa isolates. [PDF]
Multidrug-resistance patterns of P. aeruginosa isolates.
Raihana Islam (18388629) +6 more
core +1 more source
Expression and regulation of transmembrane transporters in healthy intestine and gastrointestinal diseases [PDF]
, 2006 Transmembrane transporters mediate energy dependent or independent translocation of drugs, potentially toxic compounds, and of various endogenous substrates such as bile acids and bilirubin across membranes.
Hruz, Petr
core +1 more source
Tumor Biology, 2017 Multidrug resistance in tumor cells is still a big challenge in cancer treatment. Therefore, identification ofsafe and effective multidrug resistance–reversing compounds with minimal side effects is an important approach in cancer treatment.
Bahman Yousefi +7 more
doaj +1 more source
Advanced Science, EarlyView.ABSTRACT Bacterial wound infections, particularly those caused by Escherichia coli and Pseudomonas aeruginosa, are difficult to treat due to biofilm formation, multidrug resistance, and chronic inflammation. Here, we report a multifunctional nanoplatform based on a surface‐enhanced Raman scattering (SERS) probe that enables simultaneous photodynamic ...
Hanbin Deng +6 more
wiley +1 more source
Advanced Science, EarlyView.An integrated Human Airway Microbiome Gene Catalog (iHAMGC) is constructed from 12,273 metagenomic airway samples, providing a high‐resolution reference of respiratory microbial genes. The catalog enables systematic exploration of taxonomic and functional variation across airway niches and geographic regions, revealing site‐specific and region ...
Qing Zhang +15 more
wiley +1 more source
BRCA2-Deficient Sarcomatoid Mammary Tumors Exhibit Multidrug Resistance. [PDF]
, 2015 Pan- or multidrug resistance is a central problem in clinical oncology. Here, we use a genetically engineered mouse model of BRCA2-associated hereditary breast cancer to study drug resistance to several types of chemotherapy and PARP inhibition. We found
Sol, Wendy +9 more
core +1 more source