Results 111 to 120 of about 2,406,837 (296)

Prevalence of multidrug-, extensive drug-, and pandrug-resistant commensal Escherichia coli isolated from healthy humans in community settings in low- and middle-income countries: a systematic review and meta-analysis

Global Health Action, 2019
Background The majority of existing studies aimed at investigating the incidence and prevalence of multidrug-resistance by bacteria have been performed in healthcare settings.
Nana Adoma Nkansa-Gyamfi, Joseph Kazibwe, Daouda A. K. Traore, Emmanuel Nji   +3 more
doaj   +1 more source

Allelic variations of the multidrug resistance gene determine susceptibility and disease behavior in ulcerative colitis [PDF]

, 2005
The MDR1 gene encodes P-glycoprotein 170, an efflux transporter that is highly expressed in intestinal epithelial cells. The MDR1 exonic single nucleotide polymorphisms (SNPs) C3435T and G2677T have been shown to correlate with activity/expression of P ...
Mowat, Craig, Tenesa, Albert, Arnott, Ian D, Mowat, Craig; id_orcid, Satsangi, Jack, Nimmo, Elaine R, Fennell, Janice, Nimmo, Elaine R., Arnott, Ian D., Ho, Gwo-Tzer, Drummond, Hazel   +10 more
core   +1 more source

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

Advanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella   +25 more
wiley   +1 more source

Microfluidic chip enables single-cell measurement for multidrug resistance in triple-negative breast cancer cells

, 2020
Aims: Triple-negative breast cancer patients are commonly treated with combination chemotherapy. Nonetheless, outcomes remain substandard with relapses being of a frequent occurrence.
Lopez, Jose Alejandro, Noghabi, Hamideh Sharifi, Li, PCH, Parekh, Karan, Noghabi, HS, Li, Paul Chi Hang, Parekh, K, Lopez, JA   +7 more
core   +1 more source

Randomised trial of chloroquine/sulphadoxine-pyrimethamine in Gambian children with malaria: impact against multidrug-resistant P. falciparum. [PDF]

, 2006
OBJECTIVES: In the Gambia, the combination of chloroquine (CQ) and sulphadoxine-pyrimethamine (SP) has replaced CQ monotherapy for treatment of malaria caused by Plasmodium falciparum. We measured the efficacy of the combination CQ/SP, and the prevalence
Targett Geoffrey A. T, Sutherland Colin J, Samuel Dunyo, Jawara, Musa, Coleman, Rosalind, Alexander Neal, Mesa, Eduardo, Sutherland, Colin J, Hallett, Rachel, Rachel Hallett, Ord Rosalynn, Coleman Rosalind, Musa Jawara, Geoffrey A. T Targett, Pinder Margaret, Jawara Musa, Ord, Rosalynn, Walraven, Gijs, Sowe, Maimuna, Targett, Geoffrey AT, Eduardo Mesa, Dunyo, Samuel, Neal Alexander, Colin J Sutherland, Rosalind Coleman, Gijs Walraven, Sowe Maimuna, Walraven Gijs, Mesa Eduardo, Alexander, Neal, Margaret Pinder, Dunyo Samuel, Rosalynn Ord, Maimuna Sowe, Pinder, Margaret, Hallett Rachel   +35 more
core   +1 more source

Interference of ATP‐Binding Cassette Transporter by Functional Nano‐Delivery System for High Efficiency Management of Insecticide‐Resistant Nilaparvata lugens

Advanced Science, EarlyView.
A ZIF‐90 nanocarrier delivers dinotefuran and suppresses NlABCG3 and NlABCH1 in resistant Nilaparvata lugens. This system combines pH/ATP‐triggered release with enhanced foliar retention, improving efficacy while sparing honeybees and promoting rice growth, offering a promising resistance‐breaking strategy.
Chengshuai He, Hejun Ren, Shuo Zhang, Jikang Cheng, Hui Zhang, Jiao Liu, Sijie Wang, Congfen Gao, Yanchao Zhang, Yunhao Gao   +9 more
wiley   +1 more source

Rapid Multiplex Antimicrobial Resistance Profiling and Bacterial Identification by LAP‐MALDI Mass Spectrometry Biotyping

Advanced Science, EarlyView.
Liquid atmospheric pressure matrix‐assisted laser desorption/ionization (LAP‐MALDI) mass spectrometry (MS) provides multiplexed biotyping of microbial cultures using a fast and simple workflow. This is demonstrated for clinically relevant bacteria, resulting in accurate antimicrobial resistance (AMR) detection, speciation by MS/MS sequencing and ...
Lily R. Adair, Shabnam Iyer, Ian M. Jones, Rainer Cramer   +3 more
wiley   +1 more source

Artificial Intelligence‐Guided Phenotypic Drug Repurposing Against Streptococcus pneumoniae

Advanced Science, EarlyView.
Integrated artificial intelligence (AI) ensembles identify highly potent repurposed drugs against Streptococcus pneumoniae. Prospective virtual screening of 6747 drugs uncovers nine active candidates, including thiostrepton. This drug exhibits low picomolar potency and bypasses established resistance in multidrug‐resistant strains, demonstrating an ...
Joshua S. Fitch, Muhammad D. Ariadi, Min Jung Kwun, Leonie Howells, Saiveth Hernandez‐Hernandez, Nicholas J. Croucher, Pedro J. Ballester   +6 more
wiley   +1 more source

Balaglitazone reverses P-glycoprotein-mediated multidrug resistance via upregulation of PTEN in a PPARγ-dependent manner in leukemia cells

Tumor Biology, 2017
Multidrug resistance in tumor cells is still a big challenge in cancer treatment. Therefore, identification ofsafe and effective multidrug resistance–reversing compounds with minimal side effects is an important approach in cancer treatment.
Bahman Yousefi, Ako Azimi, Maryam Majidinia, Vahid Shafiei-Irannejad, Reza Badalzadeh, Behzad Baradaran, Nosratollah Zarghami, Nasser Samadi   +7 more
doaj   +1 more source

Development of taxane resistance in a panel of human lung cancer cell lines [PDF]

, 2008
Using a selection process designed to reflect clinically relevant conditions, a panel of taxane-selected variants were developed to study further the mechanisms of resistance in lung cancer.
Keenan, Joanne, Breen, Laura, Murphy, Lisa, Clynes, Martin   +3 more
core   +2 more sources